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Exhaled nitric oxide is associated with allergic inflammation in children

Authors
 Bong Seok Choi  ;  Kyung Won Kim  ;  Yong Ju Lee  ;  Jiyoung Baek  ;  Hyun Bin Park  ;  Yoon Hee Kim  ;  Myung Hyun Sohn  ;  Kyu-Earn Kim 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.26(10) : 1265-1269, 2011 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2011
MeSH
Adolescent ; Allergens/immunology ; Animals ; Asthma/immunology* ; Breath Tests* ; Bronchial Provocation Tests ; Child ; Dermatophagoides pteronyssinus/immunology ; Eosinophil Cationic Protein/analysis ; Eosinophil Cationic Protein/blood ; Eosinophil Cationic Protein/immunology ; Eosinophils ; Exhalation ; Female ; Humans ; Hypersensitivity, Immediate/immunology* ; Immunoglobulin E/blood ; Leukocyte Count ; Male ; Nitric Oxide/analysis* ; Rhinitis, Allergic, Seasonal/immunology*
Keywords
Allergic Rhinitis ; Allergy ; Asthma ; Exhaled Nitric Oxide ; Sensitization
Abstract
Exhaled nitric oxide (eNO) has been proposed as a noninvasive marker of airway inflammation in asthma. In asthmatic patients, exhaled NO levels have been shown to relate with other markers of eosinophilic recruitment, which are detected in blood, sputum, bronchoalveolar lavage fluid and bronchial biopsy samples. The purpose of this study was to assess the possible relationship between eNO and allergic inflammation or sensitization in childhood asthma and allergic rhinitis. Subjects consisted of 118 asthmatic children, 79 patients with allergic rhinitis, and 74 controls. Their age ranged from 6 to 15 yr old. eNO level, peripheral blood eosinophil count, eosinophil cationic protein (ECP), serum total IgE level and specific IgE levels were measured. Methacholine challenge test and allergic skin prick test for common allergens were performed in all subjects. Atopic group (n = 206, 44.48 ± 30.45 ppb) had higher eNO values than non-atopic group (n = 65, 20.54 ± 16.57 ppb, P < 0.001). eNO level was significantly higher in patients with asthma (42.84 ± 31.92 ppb) and in those with allergic rhinitis (43.59 ± 29.84 ppb) than in healthy controls (27.01 ± 21.34 ppb, P < 0.001) but there was no difference between asthma and allergic rhinitis group. eNO also had significant positive correlations with Dermatophagoides pteronyssinus IgE level (r = 0.348, P < 0.001), Dermatophagoides farinae IgE level (r = 0.376, P < 0.001), and the number of positive allergens in skin prick test (r = 0.329, P = 0.001). eNO had significant positive correlations with peripheral blood eosinophil count (r = 0.356, P < 0.001), serum total IgE level (r = 0.221, P < 0.001), and ECP (r = 0.436, P < 0.001). This study reveals that eNO level is associated with allergic inflammation and the degree of allergic sensitization.
Files in This Item:
T201103029.pdf Download
DOI
10.3346/jkms.2011.26.10.1265
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Won(김경원) ORCID logo https://orcid.org/0000-0003-4529-6135
Kim, Kyu Earn(김규언)
Kim, Yoon Hee(김윤희) ORCID logo https://orcid.org/0000-0002-2149-8501
Park, Hyun Bin(박현빈)
Baek, Ji Young(백지영)
Sohn, Myung Hyun(손명현) ORCID logo https://orcid.org/0000-0002-2478-487X
Lee, Yong Ju(이용주) ORCID logo https://orcid.org/0000-0002-0796-2558
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93809
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