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Exhaled nitric oxide is associated with allergic inflammation in children

DC FieldValueLanguage
dc.contributor.author김규언-
dc.contributor.author김윤희-
dc.contributor.author박현빈-
dc.contributor.author백지영-
dc.contributor.author손명현-
dc.contributor.author이용주-
dc.contributor.author김경원-
dc.date.accessioned2014-12-20T17:01:11Z-
dc.date.available2014-12-20T17:01:11Z-
dc.date.issued2011-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93809-
dc.description.abstractExhaled nitric oxide (eNO) has been proposed as a noninvasive marker of airway inflammation in asthma. In asthmatic patients, exhaled NO levels have been shown to relate with other markers of eosinophilic recruitment, which are detected in blood, sputum, bronchoalveolar lavage fluid and bronchial biopsy samples. The purpose of this study was to assess the possible relationship between eNO and allergic inflammation or sensitization in childhood asthma and allergic rhinitis. Subjects consisted of 118 asthmatic children, 79 patients with allergic rhinitis, and 74 controls. Their age ranged from 6 to 15 yr old. eNO level, peripheral blood eosinophil count, eosinophil cationic protein (ECP), serum total IgE level and specific IgE levels were measured. Methacholine challenge test and allergic skin prick test for common allergens were performed in all subjects. Atopic group (n = 206, 44.48 ± 30.45 ppb) had higher eNO values than non-atopic group (n = 65, 20.54 ± 16.57 ppb, P < 0.001). eNO level was significantly higher in patients with asthma (42.84 ± 31.92 ppb) and in those with allergic rhinitis (43.59 ± 29.84 ppb) than in healthy controls (27.01 ± 21.34 ppb, P < 0.001) but there was no difference between asthma and allergic rhinitis group. eNO also had significant positive correlations with Dermatophagoides pteronyssinus IgE level (r = 0.348, P < 0.001), Dermatophagoides farinae IgE level (r = 0.376, P < 0.001), and the number of positive allergens in skin prick test (r = 0.329, P = 0.001). eNO had significant positive correlations with peripheral blood eosinophil count (r = 0.356, P < 0.001), serum total IgE level (r = 0.221, P < 0.001), and ECP (r = 0.436, P < 0.001). This study reveals that eNO level is associated with allergic inflammation and the degree of allergic sensitization.-
dc.description.statementOfResponsibilityopen-
dc.format.extent1265~1269-
dc.relation.isPartOfJournal of Korean Medical Science-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleExhaled nitric oxide is associated with allergic inflammation in children-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아과학)-
dc.contributor.googleauthorBong Seok Choi-
dc.contributor.googleauthorKyung Won Kim-
dc.contributor.googleauthorYong Ju Lee-
dc.contributor.googleauthorJiyoung Baek-
dc.contributor.googleauthorHyun Bin Park-
dc.contributor.googleauthorYoon Hee Kim-
dc.contributor.googleauthorMyung Hyun Sohn-
dc.contributor.googleauthorKyu-Earn Kim-
dc.identifier.doi10.3346/jkms.2011.26.10.1265-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00327-
dc.contributor.localIdA00799-
dc.contributor.localIdA01738-
dc.contributor.localIdA01838-
dc.contributor.localIdA01967-
dc.contributor.localIdA02983-
dc.contributor.localIdA00303-
dc.relation.journalcodeJ01517-
dc.contributor.alternativeNameKim, Kyu Earn-
dc.contributor.alternativeNameKim, Yoon Hee-
dc.contributor.alternativeNamePark, Hyun Bin-
dc.contributor.alternativeNameBaek, Ji Young-
dc.contributor.alternativeNameSon, Myung Hyun-
dc.contributor.alternativeNameLee, Yong Ju-
dc.contributor.alternativeNameKim, Kyung Won-
dc.contributor.affiliatedAuthorKim, Kyu Earn-
dc.contributor.affiliatedAuthorKim, Yoon Hee-
dc.contributor.affiliatedAuthorPark, Hyun Bin-
dc.contributor.affiliatedAuthorBaek, Ji Young-
dc.contributor.affiliatedAuthorSon, Myung Hyun-
dc.contributor.affiliatedAuthorLee, Yong Ju-
dc.contributor.affiliatedAuthorKim, Kyung Won-
dc.rights.accessRightsfree-
dc.citation.volume26-
dc.citation.number10-
dc.citation.startPage1265-
dc.citation.endPage1269-
dc.identifier.bibliographicCitationJournal of Korean Medical Science, Vol.26(10) : 1265-1269, 2011-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)

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