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Lymphopenia is an important prognostic factor in peripheral T-cell lymphoma (NOS) treated with anthracycline-containing chemotherapy.

 Yu Ri Kim  ;  Jin Seok Kim  ;  Soo Jeong Kim  ;  Hyun Ae Jung  ;  Seok Jin Kim  ;  Won Seog Kim  ;  Hye Won Lee  ;  Hyeon Seok Eom  ;  Seong Hyun Jeong  ;  Joon Seong Park  ;  June-Won Cheong  ;  Yoo Hong Min 
 Journal of Hematology & Oncology, Vol.4 : 34-34, 2011 
Journal Title
 Journal of Hematology & Oncology 
Issue Date
BACKGROUND: Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is a heterogeneous group of aggressive T-cell lymphomas with poor treatment outcomes. The aim of this study was to evaluate whether lymphopenia at diagnosis would have an adverse effect on survival in patients with PTCL-NOS treated with anthracycline-containing chemotherapy. METHODS: A total of 118 patients with PTCL-NOS treated with anthracycline-containing chemotherapy from 4 Korean institutions were included. RESULTS: Thirty-six patients (30.5%) had a low absolute lymphocyte count (ALC, < 1.0 × 109/L) at diagnosis. Patients with lymphopenia had shorter overall survival (OS) and progression-free survival (PFS) rates compared with patients with high ALCs (P = 0.003, P = 0.012, respectively). In multivariate analysis, high-intermediate/high-risk International Prognostic Index (IPI) scores and lymphopenia were both associated with shorter OS and PFS. Treatment-related mortality was 25.0% in the low ALC group and 4.8% in the high ALC group (P = 0.003). In patients considered high-intermediate/high-risk based on IPI scores, lymphopenia was also associated with shorter OS and PFS (P = 0.002, P = 0.001, respectively). CONCLUSION: This study suggests that lymphopenia could be an independent prognostic marker to predict unfavorable OS and PFS in patients with PTCL-NOS treated with anthracycline-containing chemotherapy and can be used to further stratify high-risk patients using IPI scores.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김수정(Kim, Soo Jeong) ; 김유리(Kim, Yu Ri) ; 김진석(Kim, Jin Seok) ; 민유홍(Min, Yoo Hong) ; 정준원(Cheong, June-Won)
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