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The Clinical Significance of CD4 Counts in Asian and Caucasian HIV-Infected Populations: Results from TAHOD and AHOD

 Amit C. Achhra  ;  Jialun Zhou  ;  Jun Yong Choi  ;  Jennifer Hoy  ;  Fujie Zhang,  ;  David J. Templeton  ;  Tuti Merati  ;  Ian Woolley  ;  Kathy Petoumenos  ;  Janaki Amin 
 Journal of the International Association of Physicians in Aids Care, Vol.10(3) : 160-170, 2011 
Journal Title
 Journal of the International Association of Physicians in Aids Care 
Issue Date
Anti-HIV Agents*/therapeutic use ; Asia ; Australia ; CD4 Lymphocyte Count* ; HIV Infections/drug therapy ; Humans
Asians ; Caucasian race ; CD4 counts ; cohort analysis ; ethnicity
The significance of interethnic variation in CD4 counts between Asian and Caucasian populations is not known. Patients on combination antiretroviral therapy from Treat Asia and Australian HIV Observational Databases (TAHOD, predominantly Asian, n = 3356; and AHOD, predominantly Caucasian, n = 2312, respectively) were followed for 23 144 person-years for AIDS/death and all-cause mortality endpoints. We calculated incidence-rates and used adjusted Cox regression to test for the interaction between cohort (TAHOD/AHOD) and time-updated CD4 count category (lagged by 3 months) for each of the endpoints. There were 382 AIDS/death events in TAHOD (rate: 4.06, 95%CI: 3.68-4.50) and 305 in AHOD (rate: 2.39, 95%CI: 2.13-2.67), per 100 person-years. At any given CD4 count category, the incidence-rates of endpoints were found to be similar between TAHOD and AHOD (in the adjusted models, P > .05 for the interaction term between cohort type and latest CD4 counts). At any given CD4 count, risk of AIDS or death was not found to vary by ethnicity, suggesting that the CD4 count thresholds for predicting outcomes defined in Caucasian populations may be equally valid in Asian populations.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
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