202 200

Cited 16 times in

Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans

 Eun Seok Kang  ;  Faidon Magkos  ;  Elizabeth Sienkiewicz  ;  Christos S. Mantzoros 
 EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol.164(6) : 911-917, 2011 
Journal Title
Issue Date
Adult ; Amenorrhea/blood ; Double-Blind Method ; Energy Intake/physiology* ; Enzyme-Linked Immunosorbent Assay ; Exercise/physiology ; Fasting/physiology ; Female ; Hormone Replacement Therapy ; Humans ; Hypothalamic Diseases/blood ; Leptin/blood ; Leptin/pharmacology* ; Leptin/therapeutic use ; Male ; Nicotinamide Phosphoribosyltransferase/blood* ; Serpins/blood* ; Young Adult
Energy deprivation ; hypothalamic amenorrhea ; metreleptin ; adipokines
OBJECTIVE: Animal and in vitro studies indicate that leptin alleviates starvation-induced reduction in circulating vaspin and stimulates the production of visfatin. We thus examined whether vaspin and visfatin are affected by short- and long-term energy deprivation and leptin administration in human subjects in vivo. DESIGN AND METHODS: We measured circulating levels of vaspin and visfatin i) before and after 72 h of starvation (leading to severe hypoleptinemia) with or without leptin administration in replacement doses in 13 normal-weight subjects, ii) before and after 72 h of starvation with leptin administration in pharmacological doses in 13 lean and obese subjects, iii) during chronic energy deficiency in eight women with hypothalamic amenorrhea on leptin replacement for 3 months, and iv) during chronic energy deficiency in 18 women with hypothalamic amenorrhea on leptin replacement or placebo for 3 months. RESULTS: Acute starvation decreased serum leptin to 21% of baseline values, (P=0.002) but had no significant effect on vaspin and visfatin concentrations (P>0.05). Nor did normalization of leptin levels affect the concentrations of these two adipokines (P>0.9). Leptin replacement in women with hypothalamic amenorrhea did not significantly alter vaspin and visfatin concentrations, whether relative to baseline or placebo administration (P>0.25). Pharmacological doses of leptin did not affect circulating vaspin and visfatin concentrations (P>0.9). CONCLUSIONS: Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency leading to hypoleptinemia and are not regulated by leptin in human subjects, indicating that these adipocyte-secreted hormonal regulators of metabolism are independently regulated in humans.
Files in This Item:
T201102754.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.