Cited 17 times in
Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.date.accessioned | 2014-12-20T16:57:02Z | - |
dc.date.available | 2014-12-20T16:57:02Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0804-4643 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93686 | - |
dc.description.abstract | OBJECTIVE: Animal and in vitro studies indicate that leptin alleviates starvation-induced reduction in circulating vaspin and stimulates the production of visfatin. We thus examined whether vaspin and visfatin are affected by short- and long-term energy deprivation and leptin administration in human subjects in vivo. DESIGN AND METHODS: We measured circulating levels of vaspin and visfatin i) before and after 72 h of starvation (leading to severe hypoleptinemia) with or without leptin administration in replacement doses in 13 normal-weight subjects, ii) before and after 72 h of starvation with leptin administration in pharmacological doses in 13 lean and obese subjects, iii) during chronic energy deficiency in eight women with hypothalamic amenorrhea on leptin replacement for 3 months, and iv) during chronic energy deficiency in 18 women with hypothalamic amenorrhea on leptin replacement or placebo for 3 months. RESULTS: Acute starvation decreased serum leptin to 21% of baseline values, (P=0.002) but had no significant effect on vaspin and visfatin concentrations (P>0.05). Nor did normalization of leptin levels affect the concentrations of these two adipokines (P>0.9). Leptin replacement in women with hypothalamic amenorrhea did not significantly alter vaspin and visfatin concentrations, whether relative to baseline or placebo administration (P>0.25). Pharmacological doses of leptin did not affect circulating vaspin and visfatin concentrations (P>0.9). CONCLUSIONS: Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency leading to hypoleptinemia and are not regulated by leptin in human subjects, indicating that these adipocyte-secreted hormonal regulators of metabolism are independently regulated in humans. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 911~917 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF ENDOCRINOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Amenorrhea/blood | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Energy Intake/physiology* | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Exercise/physiology | - |
dc.subject.MESH | Fasting/physiology | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Hormone Replacement Therapy | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypothalamic Diseases/blood | - |
dc.subject.MESH | Leptin/blood | - |
dc.subject.MESH | Leptin/pharmacology* | - |
dc.subject.MESH | Leptin/therapeutic use | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Nicotinamide Phosphoribosyltransferase/blood* | - |
dc.subject.MESH | Serpins/blood* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Circulating vaspin and visfatin are not affected by acute or chronic energy deficiency or leptin administration in humans | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | Faidon Magkos | - |
dc.contributor.googleauthor | Elizabeth Sienkiewicz | - |
dc.contributor.googleauthor | Christos S. Mantzoros | - |
dc.identifier.doi | 10.1530/EJE-11-0052 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00068 | - |
dc.relation.journalcode | J00819 | - |
dc.identifier.eissn | 1479-683X | - |
dc.identifier.pmid | 21422197 | - |
dc.subject.keyword | Energy deprivation | - |
dc.subject.keyword | hypothalamic amenorrhea | - |
dc.subject.keyword | metreleptin | - |
dc.subject.keyword | adipokines | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 164 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 911 | - |
dc.citation.endPage | 917 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF ENDOCRINOLOGY, Vol.164(6) : 911-917, 2011 | - |
dc.identifier.rimsid | 28393 | - |
dc.type.rims | ART | - |
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