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HER-2 protein overexpressing breast cancer without gene amplification shows higher hormone receptor expression than HER-2 protein overexpressing breast cancer with gene amplification

Authors
 Ja Seung Koo  ;  Woohee Jung  ;  Woo Ick Yang 
Citation
 INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, Vol.19(4) : 425-432, 2011 
Journal Title
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY
ISSN
 1066-8969 
Issue Date
2011
MeSH
Biomarkers, Tumor/metabolism ; Breast Neoplasms/genetics* ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Carcinoma, Ductal, Breast/genetics* ; Carcinoma, Ductal, Breast/metabolism ; Carcinoma, Ductal, Breast/secondary ; Chromosome Aberrations ; Female ; Gene Amplification* ; Gene Expression Profiling ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Neoplasm Grading ; Neoplasm Staging ; Receptor, ErbB-2/genetics* ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism* ; Receptors, Progesterone/metabolism*
Keywords
breast cancer ; HER-2 ; immunohistochemistry ; fluorescent in situ hybridization
Abstract
Cases of breast cancer showing human epidermal growth factor receptor-2 (HER-2) protein overexpression without corresponding gene amplification have been found in immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH) results. We investigated the clinicopathological characteristics of cases showing HER-2 protein overexpression breast cancer without gene amplification (IHC3+/FISH-) and compared them to cases showing HER-2 protein overexpression breast cancer with gene amplification (IHC3+/FISH+). This study was conducted on 90 patients with HER-2 IHC3+ breast cancer. The clinicopathological factors analyzed included tumor size, histological grade, nuclear grade, nodal involvement, and hormone receptor status. HER-2 IHC3+/FISH- breast cancer was found in 14 of 84 tumors (16.7%) and showed a statistically significant lower histological and nuclear grade (P = .000) and higher expression of estrogen receptors (ERs) and progesterone receptors (PRs) (P = .006) than IHC3+/FISH+ breast cancer. In conclusion, HER-2 IHC3+/FISH- breast cancer could be a subgroup showing lower histological/nuclear grade and higher expression of ERs/PRs.
Full Text
http://ijs.sagepub.com/content/19/4/425.abstract
DOI
10.1177/1066896909335821
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Jung, Woo Hee(정우희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93675
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