Cited 4 times in
HER-2 protein overexpressing breast cancer without gene amplification shows higher hormone receptor expression than HER-2 protein overexpressing breast cancer with gene amplification
DC Field | Value | Language |
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dc.contributor.author | 구자승 | - |
dc.contributor.author | 양우익 | - |
dc.contributor.author | 정우희 | - |
dc.date.accessioned | 2014-12-20T16:56:42Z | - |
dc.date.available | 2014-12-20T16:56:42Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1066-8969 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93675 | - |
dc.description.abstract | Cases of breast cancer showing human epidermal growth factor receptor-2 (HER-2) protein overexpression without corresponding gene amplification have been found in immunohistochemistry (IHC) and fluorescent in situ hybridization (FISH) results. We investigated the clinicopathological characteristics of cases showing HER-2 protein overexpression breast cancer without gene amplification (IHC3+/FISH-) and compared them to cases showing HER-2 protein overexpression breast cancer with gene amplification (IHC3+/FISH+). This study was conducted on 90 patients with HER-2 IHC3+ breast cancer. The clinicopathological factors analyzed included tumor size, histological grade, nuclear grade, nodal involvement, and hormone receptor status. HER-2 IHC3+/FISH- breast cancer was found in 14 of 84 tumors (16.7%) and showed a statistically significant lower histological and nuclear grade (P = .000) and higher expression of estrogen receptors (ERs) and progesterone receptors (PRs) (P = .006) than IHC3+/FISH+ breast cancer. In conclusion, HER-2 IHC3+/FISH- breast cancer could be a subgroup showing lower histological/nuclear grade and higher expression of ERs/PRs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 425~432 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism | - |
dc.subject.MESH | Breast Neoplasms/genetics* | - |
dc.subject.MESH | Breast Neoplasms/metabolism | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/genetics* | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/metabolism | - |
dc.subject.MESH | Carcinoma, Ductal, Breast/secondary | - |
dc.subject.MESH | Chromosome Aberrations | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Amplification* | - |
dc.subject.MESH | Gene Expression Profiling | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunohistochemistry | - |
dc.subject.MESH | In Situ Hybridization, Fluorescence | - |
dc.subject.MESH | Neoplasm Grading | - |
dc.subject.MESH | Neoplasm Staging | - |
dc.subject.MESH | Receptor, ErbB-2/genetics* | - |
dc.subject.MESH | Receptor, ErbB-2/metabolism | - |
dc.subject.MESH | Receptors, Estrogen/metabolism* | - |
dc.subject.MESH | Receptors, Progesterone/metabolism* | - |
dc.title | HER-2 protein overexpressing breast cancer without gene amplification shows higher hormone receptor expression than HER-2 protein overexpressing breast cancer with gene amplification | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pathology (병리학) | - |
dc.contributor.googleauthor | Ja Seung Koo | - |
dc.contributor.googleauthor | Woohee Jung | - |
dc.contributor.googleauthor | Woo Ick Yang | - |
dc.identifier.doi | 10.1177/1066896909335821 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00198 | - |
dc.contributor.localId | A02300 | - |
dc.contributor.localId | A03671 | - |
dc.relation.journalcode | J01164 | - |
dc.identifier.eissn | 1940-2465 | - |
dc.identifier.pmid | 19666946 | - |
dc.identifier.url | http://ijs.sagepub.com/content/19/4/425.abstract | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | HER-2 | - |
dc.subject.keyword | immunohistochemistry | - |
dc.subject.keyword | fluorescent in situ hybridization | - |
dc.contributor.alternativeName | Koo, Ja Seung | - |
dc.contributor.alternativeName | Yang, Woo Ick | - |
dc.contributor.alternativeName | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | Koo, Ja Seung | - |
dc.contributor.affiliatedAuthor | Yang, Woo Ick | - |
dc.contributor.affiliatedAuthor | Jung, Woo Hee | - |
dc.contributor.affiliatedAuthor | 구자승 | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 19 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 425 | - |
dc.citation.endPage | 432 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY, Vol.19(4) : 425-432, 2011 | - |
dc.identifier.rimsid | 28385 | - |
dc.type.rims | ART | - |
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