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Effects of α-melanocyte-stimulating hormone on calcium concentration in SZ95 sebocytes

Authors
 Sung Won Whang  ;  Sang Eun Lee  ;  Ji Min Kim  ;  Hyun Jung Kim  ;  Se Kyoo Jeong  ;  Christos C. Zouboulis  ;  Jeong Taek Seo  ;  Seung Hun Lee 
Citation
 Experimental Dermatology, Vol.20(1) : 19-23, 2011 
Journal Title
 Experimental Dermatology 
ISSN
 0906-6705 
Issue Date
2011
Abstract
Melanocortins have been implicated in human sebum secretion for a long time. However, the signalling pathways of α-melanocyte-stimulating hormone (α-MSH) in human sebocytes expressing melanocortin receptors (MC-Rs) are still poorly understood. Because calcium ions play a central role in MC-R signalling, we investigated whether α-MSH affects calcium signalling in the immortalized human sebocyte cell line SZ95. In addition, we investigated the impact of α-MSH on MC-1R expression and lipid synthesis in these cells. α-MSH increased intracellular calcium levels. α-MSH-mediated calcium mobilization originated from intracellular calcium stores and was mediated by inositol triphosphate. Moreover, α-MSH increased MC-1R immunoreactivity and lipid synthesis in SZ95 sebocytes in the presence of testosterone. Our data demonstrate that α-MSH in human sebocytes controls a key cellular signalling pathway, the calcium ion response, which may coordinate MC-1R-mediated sebum secretion
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93644
DOI
10.1111/j.1600-0625.2010.01199.x
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
Yonsei Authors
김현정(Kim, Hyun Jung) ; 서정택(Seo, Jeong Taeg) ; 이상은(Lee, Sang Eun) ; 이승헌(Lee, Seung Hun) ; 황성원(Whang, Sung Won)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2010.01199.x/abstract
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