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Effects of α-melanocyte-stimulating hormone on calcium concentration in SZ95 sebocytes

Authors
 Sung Won Whang ; Sang Eun Lee ; Seung Hun Lee ; Jeong Taek Seo ; Christos C. Zouboulis ; Se Kyoo Jeong ; Hyun Jung Kim ; Ji Min Kim 
Citation
 Experimental Dermatology, Vol.20(1) : 19~23, 2011 
Journal Title
 Experimental Dermatology 
ISSN
 0906-6705 
Issue Date
2011
Abstract
Melanocortins have been implicated in human sebum secretion for a long time. However, the signalling pathways of α-melanocyte-stimulating hormone (α-MSH) in human sebocytes expressing melanocortin receptors (MC-Rs) are still poorly understood. Because calcium ions play a central role in MC-R signalling, we investigated whether α-MSH affects calcium signalling in the immortalized human sebocyte cell line SZ95. In addition, we investigated the impact of α-MSH on MC-1R expression and lipid synthesis in these cells. α-MSH increased intracellular calcium levels. α-MSH-mediated calcium mobilization originated from intracellular calcium stores and was mediated by inositol triphosphate. Moreover, α-MSH increased MC-1R immunoreactivity and lipid synthesis in SZ95 sebocytes in the presence of testosterone. Our data demonstrate that α-MSH in human sebocytes controls a key cellular signalling pathway, the calcium ion response, which may coordinate MC-1R-mediated sebum secretion
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93644
DOI
10.1111/j.1600-0625.2010.01199.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
1. 연구논문 > 2. College of Dentistry > Dept. of Oral Biology
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2010.01199.x/abstract
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