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Effects of α-melanocyte-stimulating hormone on calcium concentration in SZ95 sebocytes

Authors
 Sung Won Whang  ;  Sang Eun Lee  ;  Ji Min Kim  ;  Hyun Jung Kim  ;  Se Kyoo Jeong  ;  Christos C. Zouboulis  ;  Jeong Taek Seo  ;  Seung Hun Lee 
Citation
 EXPERIMENTAL DERMATOLOGY, Vol.20(1) : 19-23, 2011 
Journal Title
EXPERIMENTAL DERMATOLOGY
ISSN
 0906-6705 
Issue Date
2011
MeSH
Calcium Signaling/drug effects* ; Cell Line ; Humans ; Lipids/biosynthesis ; Receptor, Melanocortin, Type 1/metabolism ; Sebaceous Glands/cytology ; Sebaceous Glands/drug effects* ; Sebaceous Glands/physiology* ; Sebum/drug effects ; Sebum/secretion ; Testosterone/pharmacology ; alpha-MSH/pharmacology*
Keywords
calcium ; a-MSH ; SZ95 sebocyte
Abstract
Melanocortins have been implicated in human sebum secretion for a long time. However, the signalling pathways of α-melanocyte-stimulating hormone (α-MSH) in human sebocytes expressing melanocortin receptors (MC-Rs) are still poorly understood. Because calcium ions play a central role in MC-R signalling, we investigated whether α-MSH affects calcium signalling in the immortalized human sebocyte cell line SZ95. In addition, we investigated the impact of α-MSH on MC-1R expression and lipid synthesis in these cells. α-MSH increased intracellular calcium levels. α-MSH-mediated calcium mobilization originated from intracellular calcium stores and was mediated by inositol triphosphate. Moreover, α-MSH increased MC-1R immunoreactivity and lipid synthesis in SZ95 sebocytes in the presence of testosterone. Our data demonstrate that α-MSH in human sebocytes controls a key cellular signalling pathway, the calcium ion response, which may coordinate MC-1R-mediated sebum secretion
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0625.2010.01199.x/abstract
DOI
10.1111/j.1600-0625.2010.01199.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyun Jung(김현정)
Seo, Jeong Taeg(서정택) ORCID logo https://orcid.org/0000-0003-2697-0251
Lee, Sang Eun(이상은) ORCID logo https://orcid.org/0000-0003-4720-9955
Lee, Seung Hun(이승헌)
Whang, Sung Won(황성원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93644
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