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Clostridium difficile 아포에 대한 소독제의 살균효과

Other Titles
 Sporicidal Activity of Selected Disinfectants against Clostridium difficile 
 김효식  ;  김희정 
 Korean Journal of Nosocomial Infection Control (병원감염관리), Vol.16(1) : 13-17, 2011 
Journal Title
Korean Journal of Nosocomial Infection Control(병원감염관리)
Issue Date
Clostridium difficile ; Disinfectant ; Spore
BACKGROUND: Clostridium difficile infection (CDI) is the predominant cause of hospital-acquired diarrhea. This study evaluated the sporicidal activities of several disinfectants against C. difficile spores. METHODS: We used toxigenic C. difficile strains with different ribotypes for our study. We compared the sporicidal activities of Cavicide (Metrex Research Corporation, USA), Cidex OPA (Advanced Sterilization Products, USA), 1% Rely+On Virkon (Dupont, UK), 0.25% Surfanios (Laboratoires Anios, France), sodium hypochlorite (Yuhan Clorox, Korea), and 70% ethyl alcohol (Duksan, Korea) by using dilution-neutralization method. The sporicidal activity of the disinfecting agents was considered to be the inactivation factor (IF). The IF was calculated as the log10 colony forming unit (CFU) reduction of the viable count from the initial inoculums. Disinfectants were considered to be sporicidal if they showed an IF> or =4. RESULTS: Cavicide, 70% ethyl alcohol, Rely+On Virkon, and Surfanios showed no reduction in spore counts at all exposure time. Solutions of sodium hypochlorite diluted 1:100 (> or =400 ppm available chlorine), 1:50, and 1:20 were sporicidal after 5 min, 2 min, and 30 s, respectively. Cidex OPA showed sporicidal activity after 30 min. CONCLUSION: To prevent the transmission of CDI, at least 1,000 ppm sodium hypochlorite solution should be used to disinfect the hospital environment. Contaminated endoscopes should be disinfected with Cidex OPA for more than 30 min
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heejung(김희정) ORCID logo https://orcid.org/0000-0002-0190-703X
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