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The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

Authors
 Ja Seung Koo  ;  Seho Park  ;  Byeong-Woo Park  ;  Sarah Lee  ;  Seung Il Kim 
Citation
 Tumor Biology, Vol.32(4) : 787-799, 2011 
Journal Title
 Tumor Biology 
ISSN
 1010-4283 
Issue Date
2011
Abstract
We aimed to investigate the expression of caveolin-1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p<0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p<0.001), high nodal stage (p=0.011), high cancer stage (p=0.005), estrogen receptor negativity (p=0.003), and tumor recurrence (p=0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p<0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93605
DOI
10.1007/s13277-011-0181-6
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
구자승(Koo, Ja Seung) ; 김승일(Kim, Seung Il) ; 박병우(Park, Byeong Woo) ; 박세호(Park, Se Ho)
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Full Text
http://link.springer.com/article/10.1007%2Fs13277-011-0181-6
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