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Cited 46 times in

The impact of caveolin protein expression in tumor stroma on prognosis of breast cancer

DC Field Value Language
dc.contributor.author구자승-
dc.contributor.author김승일-
dc.contributor.author박병우-
dc.contributor.author박세호-
dc.date.accessioned2014-12-20T16:54:27Z-
dc.date.available2014-12-20T16:54:27Z-
dc.date.issued2011-
dc.identifier.issn1010-4283-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93605-
dc.description.abstractWe aimed to investigate the expression of caveolin-1, -2, -3, and platelet-derived growth factor (PDGF) β receptor in breast cancer cells and stroma by immunohistochemistry and to analyze their implications. The expression rates of stromal caveolin-2 and PDGF β receptor increased as the tumor progressed from ductal carcinoma in situ to microinvasive ductal carcinoma, intraductal component of invasive ductal carcinoma (IDC), and IDC (p<0.001). The expression loss of caveolin-1 in tumor stroma of IDC correlated with high tumor stage (p<0.001), high nodal stage (p=0.011), high cancer stage (p=0.005), estrogen receptor negativity (p=0.003), and tumor recurrence (p=0.003). In addition, the expression loss of caveolin-1 in tumor stroma was correlated with a shorter disease-free survival and an overall survival (p<0.001). In conclusion, the loss of stromal caveolin-1 is related to poor prognosis in IDC.-
dc.description.statementOfResponsibilityopen-
dc.format.extent787~799-
dc.relation.isPartOfTUMOR BIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHBiomarkers, Tumor/analysis*-
dc.subject.MESHBiomarkers, Tumor/metabolism-
dc.subject.MESHBreast Neoplasms/metabolism*-
dc.subject.MESHBreast Neoplasms/mortality-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHCarcinoma, Ductal, Breast/metabolism*-
dc.subject.MESHCarcinoma, Ductal, Breast/mortality-
dc.subject.MESHCarcinoma, Ductal, Breast/pathology-
dc.subject.MESHCarcinoma, Intraductal, Noninfiltrating/metabolism*-
dc.subject.MESHCarcinoma, Intraductal, Noninfiltrating/mortality-
dc.subject.MESHCarcinoma, Intraductal, Noninfiltrating/pathology-
dc.subject.MESHCaveolin 1/biosynthesis*-
dc.subject.MESHCaveolins/biosynthesis-
dc.subject.MESHDisease Progression-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPlatelet-Derived Growth Factor/biosynthesis-
dc.subject.MESHPrognosis-
dc.subject.MESHTissue Array Analysis-
dc.subject.MESHTumor Microenvironment/physiology*-
dc.titleThe impact of caveolin protein expression in tumor stroma on prognosis of breast cancer-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pathology (병리학)-
dc.contributor.googleauthorJa Seung Koo-
dc.contributor.googleauthorSeho Park-
dc.contributor.googleauthorSeung Il Kim-
dc.contributor.googleauthorSarah Lee-
dc.contributor.googleauthorByeong-Woo Park-
dc.identifier.doi10.1007/s13277-011-0181-6-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00198-
dc.contributor.localIdA00658-
dc.contributor.localIdA01475-
dc.contributor.localIdA01524-
dc.relation.journalcodeJ02763-
dc.identifier.eissn1423-0380-
dc.identifier.pmid21584795-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs13277-011-0181-6-
dc.subject.keywordBreast cancer-
dc.subject.keywordCaveolin-
dc.subject.keywordImmunohistochemistry-
dc.subject.keywordStroma-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Seung Il-
dc.contributor.alternativeNamePark, Byeong Woo-
dc.contributor.alternativeNamePark, Se Ho-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Seung Il-
dc.contributor.affiliatedAuthorPark, Byeong Woo-
dc.contributor.affiliatedAuthorPark, Se Ho-
dc.contributor.affiliatedAuthor구자승-
dc.rights.accessRightsnot free-
dc.citation.volume32-
dc.citation.number4-
dc.citation.startPage787-
dc.citation.endPage799-
dc.identifier.bibliographicCitationTUMOR BIOLOGY, Vol.32(4) : 787-799, 2011-
dc.identifier.rimsid28336-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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