Cited 100 times in
Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서진석 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2014-12-20T16:53:04Z | - |
dc.date.available | 2014-12-20T16:53:04Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93561 | - |
dc.description.abstract | We fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. CD44 is closely associated with cancer growth, including proliferation, metastasis, invasion, and angiogenesis. Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Subsequently, HA-MNCs were fabricated using the nano-emulsion method; magnetic nanocrystals were simultaneously self-assembled with Py-HA conjugates, and their physical and magnetic properties depended on the degree of substitution (DS) of Py in Py-HA conjugates. HA-MNCs exhibited superior targeting efficiency with MR sensitivity as well as excellent biocompatibility through in vitro/in vivo studies. This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 7941~7950 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Breast Neoplasms/diagnosis* | - |
dc.subject.MESH | Breast Neoplasms/pathology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Cell Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyaluronan Receptors/metabolism* | - |
dc.subject.MESH | Hyaluronic Acid/chemistry* | - |
dc.subject.MESH | Hyaluronic Acid/pharmacology | - |
dc.subject.MESH | Magnetic Phenomena | - |
dc.subject.MESH | Magnetic Resonance Imaging* | - |
dc.subject.MESH | Magnetic Resonance Spectroscopy | - |
dc.subject.MESH | Magnets/chemistry* | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Micelles | - |
dc.subject.MESH | Nanoparticles/chemistry* | - |
dc.subject.MESH | Nanoparticles/ultrastructure | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Photoelectron Spectroscopy | - |
dc.subject.MESH | Spectroscopy, Fourier Transform Infrared | - |
dc.subject.MESH | Static Electricity | - |
dc.subject.MESH | Temperature | - |
dc.subject.MESH | Tissue Distribution/drug effects | - |
dc.title | Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Eun-Kyung Lim | - |
dc.contributor.googleauthor | Hyun-Ouk Kim | - |
dc.contributor.googleauthor | Eunji Jang | - |
dc.contributor.googleauthor | Joseph Park | - |
dc.contributor.googleauthor | Kwangyeol Lee | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1016/j.biomaterials.2011.06.077 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J00312 | - |
dc.identifier.eissn | 1878-5905 | - |
dc.identifier.pmid | 21777976 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0142961211007708 | - |
dc.subject.keyword | Hyaluronan | - |
dc.subject.keyword | Magnetic resonance imaging | - |
dc.subject.keyword | Magnetic nanoclusters | - |
dc.subject.keyword | CD44Breast cancer | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 32 | - |
dc.citation.number | 31 | - |
dc.citation.startPage | 7941 | - |
dc.citation.endPage | 7950 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, Vol.32(31) : 7941-7950, 2011 | - |
dc.identifier.rimsid | 28311 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.