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Hyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging.

DC FieldValueLanguage
dc.contributor.author서진석-
dc.contributor.author허용민-
dc.date.accessioned2014-12-20T16:53:04Z-
dc.date.available2014-12-20T16:53:04Z-
dc.date.issued2011-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93561-
dc.description.abstractWe fabricated hyaluronan-modified magnetic nanoclusters (HA-MNCs) for detection of CD44-overexpressing breast cancer using magnetic resonance (MR) imaging. CD44 is closely associated with cancer growth, including proliferation, metastasis, invasion, and angiogenesis. Hence, pyrenyl hyaluronan (Py-HA) conjugates were synthesized as CD44-targetable surfactants with hyaluronan (HA) and 1-pyrenylbutyric acid (Py) to modify hyaluronan on hydrophobic magnetic nanocrystals. Subsequently, HA-MNCs were fabricated using the nano-emulsion method; magnetic nanocrystals were simultaneously self-assembled with Py-HA conjugates, and their physical and magnetic properties depended on the degree of substitution (DS) of Py in Py-HA conjugates. HA-MNCs exhibited superior targeting efficiency with MR sensitivity as well as excellent biocompatibility through in vitro/in vivo studies. This suggests that HA-MNCs can be a potent cancer specific molecular imaging agent via targeted detection of CD44 with MR imaging.-
dc.description.statementOfResponsibilityopen-
dc.format.extent7941~7950-
dc.relation.isPartOfBiomaterials-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHyaluronan-modified magnetic nanoclusters for detection of CD44-overexpressing breast cancer by MR imaging.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorEun-Kyung Lim-
dc.contributor.googleauthorHyun-Ouk Kim-
dc.contributor.googleauthorEunji Jang-
dc.contributor.googleauthorJoseph Park-
dc.contributor.googleauthorKwangyeol Lee-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorYong-Min Huh-
dc.contributor.googleauthorSeungjoo Haam-
dc.identifier.doi10.1016/j.biomaterials.2011.06.077-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01916-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ00312-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0142961211007708-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.rights.accessRightsnot free-
dc.citation.volume32-
dc.citation.number31-
dc.citation.startPage7941-
dc.citation.endPage7950-
dc.identifier.bibliographicCitationBiomaterials, Vol.32(31) : 7941-7950, 2011-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실)

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