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Topiramate on the quality of life in childhood epilepsy.

Authors
 Da-Eun Jung  ;  Heung-Dong Kim  ;  Yun-Jung Hur  ;  So-Yong Eom  ;  Korean Pediatric Topiramate Study Group 
Citation
 BRAIN & DEVELOPMENT, Vol.33(9) : 707-712, 2011 
Journal Title
 BRAIN & DEVELOPMENT 
ISSN
 0387-7604 
Issue Date
2011
MeSH
Adolescent ; Anticonvulsants/therapeutic use* ; Child ; Child, Preschool ; Epilepsy/drug therapy* ; Epilepsy/psychology* ; Female ; Fructose/analogs & derivatives* ; Fructose/therapeutic use ; Humans ; Male ; Prospective Studies ; Quality of Life* ; Surveys and Questionnaires ; Treatment Outcome
Keywords
Childhood epilepsy ; Quality of life ; Topiramate
Abstract
This study evaluated the effect of topiramate (TPM) on the quality of life (QOL) in childhood epilepsy, using the Korean quality of life in childhood epilepsy (K-QOLCE) questionnaire. An open label, prospective, observational study of the families of 664 children with epilepsy from 41 centers was conducted. The parents completed the K-QOLCE at the baseline visit and again 6months after starting TPM treatment. The parents reported the seizure frequency at both assessment dates. Statistically significant improvements in all K-QOLCE domains except social functioning were found at 6months after starting TPM treatment from the baseline-scores (P<0.05). However, improved QOL scores were not dependent on the reduction in seizure frequency. TPM significantly improved QOL in children with epilepsy, suggesting its potential clinical benefits.
Full Text
http://www.sciencedirect.com/science/article/pii/S0387760410002986
DOI
10.1016/j.braindev.2010.11.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Heung Dong(김흥동) ORCID logo https://orcid.org/0000-0002-8031-7336
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93558
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