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Topiramate on the quality of life in childhood epilepsy.

Authors
 Da-Eun Jung  ;  Heung-Dong Kim  ;  Yun-Jung Hur  ;  So-Yong Eom  ;  Korean Pediatric Topiramate Study Group 
Citation
 Brain & Development, Vol.33(9) : 707-712, 2011 
Journal Title
 Brain & Development 
ISSN
 0387-7604 
Issue Date
2011
Abstract
This study evaluated the effect of topiramate (TPM) on the quality of life (QOL) in childhood epilepsy, using the Korean quality of life in childhood epilepsy (K-QOLCE) questionnaire. An open label, prospective, observational study of the families of 664 children with epilepsy from 41 centers was conducted. The parents completed the K-QOLCE at the baseline visit and again 6months after starting TPM treatment. The parents reported the seizure frequency at both assessment dates. Statistically significant improvements in all K-QOLCE domains except social functioning were found at 6months after starting TPM treatment from the baseline-scores (P<0.05). However, improved QOL scores were not dependent on the reduction in seizure frequency. TPM significantly improved QOL in children with epilepsy, suggesting its potential clinical benefits.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93558
Full Text
http://www.sciencedirect.com/science/article/pii/S0387760410002986
DOI
10.1016/j.braindev.2010.11.011
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김흥동(Kim, Heung Dong)
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