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Expression of a soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) correlates with clinical disease activity in intestinal Behcet's disease

Authors
 Jung, Yoon Suk  ;  Kim, Seung Won  ;  Yoon, Jin Young  ;  Lee, Jin Ha  ;  Jeon, Soung Min  ;  Hong, Sung Pil  ;  Kim, Tae Il  ;  Kim, Won Ho  ;  Cheon, Jae Hee 
Citation
 Inflammatory Bowel Diseases, Vol.17(10) : 2130-2137, 2011 
Journal Title
 Inflammatory Bowel Diseases 
ISSN
 1078-0998 
Issue Date
2011
Abstract
BACKGROUND: No serological marker currently exists to assess disease activity in patients with intestinal Behcet's disease (BD). We conducted this study to determine if the expression level of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) can be used as a biological marker to assess disease activity in intestinal BD. METHODS: A total of 88 patients with intestinal BD were enrolled prospectively. We assessed their clinical disease activities using the disease activity index for intestinal BD (DAIBD). At the time that the DAIBD was assessed, serum erythrocyte sedimentation rate (ESR) as well as levels of TREM-1, C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) were measured. RESULTS: The mean ESR and mean levels of sTREM-1, CRP, and TNF-α in patients with intestinal BD were significantly higher than those in healthy controls. Levels of sTREM-1 were the most highly correlated with disease activity (r = 0.762 for the DAIBD score), followed by CRP levels (r = 0.383 for the DAIBD score) and ESR (r = 0.236 for the DAIBD score). However, serum levels of TNF-α level were not correlated with disease activity (r = -0.017 for the DAIBD score). CONCLUSIONS: Serum sTREM-1 levels were more highly correlated with disease activity than were CRP levels or ESR in patients with intestinal BD, suggesting that serum sTREM-1 level could be a potential marker for the assessment of disease activity of intestinal BD.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93547
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00054725-201110000-00012&LSLINK=80&D=ovft
DOI
10.1002/ibd.21600
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
Yonsei Authors
김승원(Kim, Seung Won)
김원호(Kim, Won Ho)
김태일(Kim, Tae Il)
윤진영(Yoon, Jin Young)
전승민(Jeon, Soung Min)
정윤숙(Jung, Yoon Suk)
천재희(Cheon, Jae Hee)
홍성필(Hong, Sung Pil)
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