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Expression of a soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) correlates with clinical disease activity in intestinal Behcet's disease

 Jung, Yoon Suk  ;  Kim, Seung Won  ;  Yoon, Jin Young  ;  Lee, Jin Ha  ;  Jeon, Soung Min  ;  Hong, Sung Pil  ;  Kim, Tae Il  ;  Kim, Won Ho  ;  Cheon, Jae Hee 
 INFLAMMATORY BOWEL DISEASES, Vol.17(10) : 2130-2137, 2011 
Journal Title
Issue Date
Adult ; Behcet Syndrome/blood* ; Behcet Syndrome/diagnosis ; Biomarkers/blood* ; Blood Sedimentation ; C-Reactive Protein/metabolism ; Case-Control Studies ; Cohort Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Humans ; Intestinal Diseases/blood* ; Intestinal Diseases/diagnosis ; Male ; Membrane Glycoproteins/blood* ; Prognosis ; Prospective Studies ; Receptors, Immunologic/blood* ; Severity of Illness Index ; Triggering Receptor Expressed on Myeloid Cells-1 ; Tumor Necrosis Factor-alpha/blood
triggering receptor expressed on myeloid cells-1 ; C-reactive protein ; erythrocyte sedimentation rate ; tumor necrosis factor-a ; intestinal Behcet’s disease ; disease activity index
BACKGROUND: No serological marker currently exists to assess disease activity in patients with intestinal Behcet's disease (BD). We conducted this study to determine if the expression level of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) can be used as a biological marker to assess disease activity in intestinal BD. METHODS: A total of 88 patients with intestinal BD were enrolled prospectively. We assessed their clinical disease activities using the disease activity index for intestinal BD (DAIBD). At the time that the DAIBD was assessed, serum erythrocyte sedimentation rate (ESR) as well as levels of TREM-1, C-reactive protein (CRP), and tumor necrosis factor-α (TNF-α) were measured. RESULTS: The mean ESR and mean levels of sTREM-1, CRP, and TNF-α in patients with intestinal BD were significantly higher than those in healthy controls. Levels of sTREM-1 were the most highly correlated with disease activity (r = 0.762 for the DAIBD score), followed by CRP levels (r = 0.383 for the DAIBD score) and ESR (r = 0.236 for the DAIBD score). However, serum levels of TNF-α level were not correlated with disease activity (r = -0.017 for the DAIBD score). CONCLUSIONS: Serum sTREM-1 levels were more highly correlated with disease activity than were CRP levels or ESR in patients with intestinal BD, suggesting that serum sTREM-1 level could be a potential marker for the assessment of disease activity of intestinal BD.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Kim, Seung Won(김승원) ORCID logo https://orcid.org/0000-0002-1692-1192
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Yoon, Jin Young(윤진영)
Jeon, Soung Min(전승민)
Jung, Yoon Suk(정윤숙)
Cheon, Jae Hee(천재희) ORCID logo https://orcid.org/0000-0002-2282-8904
Hong, Sung Pil(홍성필)
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