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Factors associated with participation in providing buccal cell DNA for a genetic epidemiologic study

 Kang D.R.  ;  Kim C.  ;  Hur N.W.  ;  Shim J.S.  ;  Shin S.C.  ;  Suh I. 
 Public Health Genomics, Vol.14(3) : 127-134, 2011 
Journal Title
 Public Health Genomics 
Issue Date
AIMS: Our aim was to investigate factors associated with participation in buccal cell DNA collection using a large-scale prospective cohort study. METHODS: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal cell collection kits were mailed and collected from March to September 2004. Epidemiologic characteristics measured at baseline (1990 or 1992) and during follow-up (1998) were compared between respondents and nonrespondents. RESULTS: Among the 13,084 (29.2%) respondents, 78.7% submitted usable samples (DNA concentration ≥3 μg). After adjustments for either or both age and family history of chronic disease, participation in men was positively associated with old age, a family history of chronic disease, low subjective health status, and regular exercise, and negatively associated with current smoking status. In women, only old age was associated with participation. Low body mass index (BMI) (<18.5 kg/m(2)), blood pressure, total cholesterol, and fasting blood glucose level were negatively associated with participation in men after adjustments for age and family history of chronic disease, but not in women, except for low BMI. CONCLUSIONS: In this study, collecting buccal cell DNA by mailed survey has a low success rate (29%), and there appear to be a nonresponse bias and gender differences in the collection process.
Appears in Collections:
1. Journal Papers (연구논문) > 4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원)
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Institute for Environmental Research (환경공해연구소)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실)
Yonsei Authors
강대용(Kang, Dae Ryong) ; 김창수(Kim, Chang Soo) ; 서일(Suh, Il) ; 허남욱(Hur, Nam Wook)
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