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Factors associated with participation in providing buccal cell DNA for a genetic epidemiologic study

 Kang D.R.  ;  Kim C.  ;  Hur N.W.  ;  Shim J.S.  ;  Shin S.C.  ;  Suh I. 
 PUBLIC HEALTH GENOMICS, Vol.14(3) : 127-134, 2011 
Journal Title
Issue Date
Adult ; Blood Pressure ; Body Mass Index ; Cholesterol/blood ; DNA/genetics* ; Female ; Health Status Indicators ; Humans ; Life Style ; Male ; Middle Aged ; Molecular Epidemiology* ; Mouth Mucosa/metabolism* ; Prospective Studies ; Republic of Korea/epidemiology
Biological sample ; Participant recruitment ; Primary health care ; Survey research
AIMS: Our aim was to investigate factors associated with participation in buccal cell DNA collection using a large-scale prospective cohort study. METHODS: Of the 183,634 Korea Medical Insurance Corporation (KMIC) prospective cohort study enrollees, 44,773 (36,794 men) were randomly selected. Buccal cell collection kits were mailed and collected from March to September 2004. Epidemiologic characteristics measured at baseline (1990 or 1992) and during follow-up (1998) were compared between respondents and nonrespondents. RESULTS: Among the 13,084 (29.2%) respondents, 78.7% submitted usable samples (DNA concentration ≥3 μg). After adjustments for either or both age and family history of chronic disease, participation in men was positively associated with old age, a family history of chronic disease, low subjective health status, and regular exercise, and negatively associated with current smoking status. In women, only old age was associated with participation. Low body mass index (BMI) (<18.5 kg/m(2)), blood pressure, total cholesterol, and fasting blood glucose level were negatively associated with participation in men after adjustments for age and family history of chronic disease, but not in women, except for low BMI. CONCLUSIONS: In this study, collecting buccal cell DNA by mailed survey has a low success rate (29%), and there appear to be a nonresponse bias and gender differences in the collection process.
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4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
5. Research Institutes (연구소) > Institute for Environmental Research (환경공해연구소) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kang, Dae Ryong(강대용)
Kim, Chang Soo(김창수) ORCID logo https://orcid.org/0000-0002-5940-5649
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Hur, Nam Wook(허남욱)
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