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Delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of NF-κB acetylation in fibroblast-like synoviocyte MH7A cells.

Authors
 Ah-Reum Seong ; Jung-Yoon Yoo ; Ho-Geun Yoon ; Sunoh Kim ; Woojin Jun ; Jeongmin Lee ; Yoo-Hyun Lee ; Mee-Hee Lee ; KyungChul Choi 
Citation
 Biochemical and Biophysicial Research Communications, Vol.410(3) : 581~586, 2011 
Journal Title
 Biochemical and Biophysicial Research Communications 
ISSN
 0006-291X 
Issue Date
2011
Abstract
Histone acetyltransferase (HAT) inhibitors (HATi) isolated from dietary compounds have been shown to suppress inflammatory signaling, which contributes to rheumatoid arthritis. Here, we identified a novel HATi in Punica granatum L. known as delphinidin (DP). DP did not affect the activity of other epigenetic enzymes (histone deacetylase, histone methyltransferase, or sirtuin1). DP specifically inhibited the HAT activities of p300/CBP. It also inhibited p65 acetylation in MH7A cells, a human rheumatoid arthritis synovial cell line. DP-induced hypoacetylation was accompanied by cytosolic accumulation of p65 and nuclear localization of IKBα. Accordingly, DP treatment inhibited TNFα-stimulated increases in NF-κB function and expression of NF-κB target genes in these cells. Importantly, DP suppressed lipopolysaccharide-induced pro-inflammatory cytokine expression in Jurkat T lymphocytes, demonstrating that HATi efficiently suppresses cytokine-mediated immune responses. Together, these results show that the HATi activity of DP counters anti-inflammatory signaling by blocking p65 acetylation and that this compound may be useful in preventing inflammatory arthritis.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93501
DOI
10.1016/j.bbrc.2011.06.029
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Life Science
1. 연구논문 > 1. College of Medicine > Dept. of Biochemistry & Molecular Biology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0006291X11009879
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