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Ambidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs

DC Field Value Language
dc.contributor.author서진석-
dc.contributor.author양재문-
dc.contributor.author허용민-
dc.date.accessioned2014-12-20T16:49:13Z-
dc.date.available2014-12-20T16:49:13Z-
dc.date.issued2011-
dc.identifier.issn0142-9612-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/93439-
dc.description.abstractThe synchronization of gene expression and cell trafficking in transfected stem cells is crucial for augmentation of stem cell functions (differentiation and neurotropic factor secretion) and real time in vivo monitoring. We report a magnetic nanoparticle-based gene delivery system that can ensure simultaneous gene delivery and in vivo cell trafficking by high resolution MR imaging. The polar aprotic solvent soluble MnFe₂O₄ nanoparticles were enveloped using cationic polymers (branched polyethyleneimine, PEI) by the solvent shifting method for a gene loading. Using our magnetic nanovector system (PEI-coated MnFe₂O₄ nanoparticles), thus, we synchronized stem cell migration and its gene expression in a rat stroke mod-
dc.description.statementOfResponsibilityopen-
dc.format.extent6174~6182-
dc.relation.isPartOfBIOMATERIALS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCells, Cultured-
dc.subject.MESHGenetic Vectors/chemistry*-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMagnetics*-
dc.subject.MESHMesenchymal Stromal Cells/chemistry-
dc.subject.MESHMesenchymal Stromal Cells/metabolism*-
dc.subject.MESHNanoparticles/chemistry*-
dc.subject.MESHRats-
dc.subject.MESHSpectroscopy, Fourier Transform Infrared-
dc.subject.MESHTransfection/methods*-
dc.titleAmbidextrous magnetic nanovectors for synchronous gene transfection and labeling of human MSCs-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Radiology (영상의학)-
dc.contributor.googleauthorJaemoon Yang-
dc.contributor.googleauthorEun-Sook Lee-
dc.contributor.googleauthorMin-Young Noh-
dc.contributor.googleauthorSeong-Ho Koh-
dc.contributor.googleauthorEun-Kyung Lim-
dc.contributor.googleauthorA-Rum Yoo-
dc.contributor.googleauthorKwangyeol Lee-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorSeung Hyun Kim-
dc.contributor.googleauthorSeungjoo Haam-
dc.contributor.googleauthorYong-Min Huh-
dc.identifier.doi10.1016/j.biomaterials.2011.04.007-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA02315-
dc.contributor.localIdA01916-
dc.contributor.localIdA04359-
dc.relation.journalcodeJ00312-
dc.identifier.eissn1878-5905-
dc.identifier.pmid21696819-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0142961211003899-
dc.subject.keywordMagnetic-
dc.subject.keywordNanovectors-
dc.subject.keywordGene deliveryStem cell-
dc.subject.keywordSolvent shifting-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.alternativeNameHuh, Yong Min-
dc.contributor.affiliatedAuthorYang, Jae Moon-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.contributor.affiliatedAuthorHuh, Yong Min-
dc.rights.accessRightsnot free-
dc.citation.volume32-
dc.citation.number26-
dc.citation.startPage6174-
dc.citation.endPage6182-
dc.identifier.bibliographicCitationBIOMATERIALS, Vol.32(26) : 6174-6182, 2011-
dc.identifier.rimsid28234-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
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