Cited 8 times in
Effect of globular adiponectin on interleukin-6 and interleukin-8 expression in periodontal ligament and gingival fibroblasts
DC Field | Value | Language |
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dc.contributor.author | 김지혜 | - |
dc.contributor.author | 박은정 | - |
dc.contributor.author | 박홍규 | - |
dc.contributor.author | 유윤정 | - |
dc.contributor.author | 이양신 | - |
dc.contributor.author | 차정헌 | - |
dc.contributor.author | 최성호 | - |
dc.date.accessioned | 2014-12-20T16:48:31Z | - |
dc.date.available | 2014-12-20T16:48:31Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 2093-2278 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93417 | - |
dc.description.abstract | PURPOSE: Globular adiponectin (gAd) is a type of adipocytokine, which is mainly produced by adipose tissue. It has been reported that gAd acts as a pro- as well as an anti-inflammatory factor. Interleukin (IL)-6 and IL-8 are pro-inflammatory cytokines. To investigate the role of gAd on periodontal tissues, the expression of adiponectin receptor 1 (AdipoR1) and the effect of gAd on the expression of IL-6 and IL-8 were investigated in periodontal ligament (PDL) and gingival fibroblasts. METHODS: PDL and gingival fibroblasts were cultured from human periodontal tissues. gAd derived from Escherichia coli and murine myeloma cells were used. The expression of AdipoR1 was estimated by reverse transcription-polymerase chain reaction and western blot. The expression of cytokines was measured by enzyme-linked immunosorbent assay. RESULTS: PDL and gingival fibroblasts expressed both mRNA and protein of AdipoR1. gAd derived from E. coli increased the production of IL-6 and IL-8, but polymyxin B, an inhibitor of lipopolysaccharide (LPS), inhibited IL-6 and IL-8 production induced by gAd in both types of cells. gAd derived from murine myeloma cells did not induce IL-6 and IL-8 production in those cells. gAd derived from E. coli contained higher levels of LPS than gAd derived from murine myeloma cells. LPS increased production of IL-6 and IL-8 in PDL and gingival fibroblasts, but pretreatment of cells with gAd derived from murine myeloma cells did not inhibit LPS-induced IL-6 and IL-8 expression. CONCLUSIONS: Our results suggest that PDL and gingival fibroblasts express AdipoR1 and that gAd does not act as a modulator of IL-6 and IL-8 expression in PDL and gingival fibroblasts. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 149~156 | - |
dc.relation.isPartOf | JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Effect of globular adiponectin on interleukin-6 and interleukin-8 expression in periodontal ligament and gingival fibroblasts | - |
dc.type | Article | - |
dc.contributor.college | College of Dentistry (치과대학) | - |
dc.contributor.department | Dept. of Oral Biology (구강생물학) | - |
dc.contributor.googleauthor | Hong Gyu Park | - |
dc.contributor.googleauthor | Eun Jung Bak | - |
dc.contributor.googleauthor | Ji Hye Kim | - |
dc.contributor.googleauthor | Yang-Sin Lee | - |
dc.contributor.googleauthor | Seong-Ho Choi | - |
dc.contributor.googleauthor | Jeong-Heon Cha | - |
dc.contributor.googleauthor | Yun-Jung Yoo | - |
dc.identifier.doi | 10.5051/jpis.2011.41.3.149 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01614 | - |
dc.contributor.localId | A01771 | - |
dc.contributor.localId | A02490 | - |
dc.contributor.localId | A02948 | - |
dc.contributor.localId | A04007 | - |
dc.contributor.localId | A04081 | - |
dc.contributor.localId | A01000 | - |
dc.relation.journalcode | J01695 | - |
dc.identifier.eissn | 2093-2286 | - |
dc.identifier.pmid | 21811691 | - |
dc.subject.keyword | Adiponectin | - |
dc.subject.keyword | Cytokines | - |
dc.subject.keyword | Fibroblasts | - |
dc.subject.keyword | Periodontalligament | - |
dc.subject.keyword | Receptors | - |
dc.contributor.alternativeName | Kim, Ji Hye | - |
dc.contributor.alternativeName | Bak, Eun-Jung | - |
dc.contributor.alternativeName | Park, Hong Gyu | - |
dc.contributor.alternativeName | Yoo, Yun Jung | - |
dc.contributor.alternativeName | Lee, Yang Sin | - |
dc.contributor.alternativeName | Cha, Jung Heon | - |
dc.contributor.alternativeName | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Bak, Eun-Jung | - |
dc.contributor.affiliatedAuthor | Park, Hong Gyu | - |
dc.contributor.affiliatedAuthor | Yoo, Yun Jung | - |
dc.contributor.affiliatedAuthor | Lee, Yang Sin | - |
dc.contributor.affiliatedAuthor | Cha, Jung Heon | - |
dc.contributor.affiliatedAuthor | Choi, Seong Ho | - |
dc.contributor.affiliatedAuthor | Kim, Ji Hye | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 41 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 149 | - |
dc.citation.endPage | 156 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PERIODONTAL AND IMPLANT SCIENCE, Vol.41(3) : 149-156, 2011 | - |
dc.identifier.rimsid | 27647 | - |
dc.type.rims | ART | - |
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