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5-Lipoxygenase-activating protein (FLAP) inhibitor MK-0591 prevents aberrant alveolarization in newborn mice exposed to 85% oxygen in a dose- and time-dependent manner

Authors
 Min Soo Park  ;  Myung Hyun Sohn  ;  Chul Lee  ;  Ran Namgung  ;  Moon Sung Park  ;  Kyu-Earn Kim 
Citation
 Lung, Vol.189(1) : 43-50, 2011 
Journal Title
 Lung 
ISSN
 0341-2040 
Issue Date
2011
Abstract
Bronchopulmonary dysplasia is characterized by prolonged oxygen dependency due to compromised gas-exchange capability. This is attributable mainly to inadequate and aberrant alveolarization resulting from insults like hyperoxia. Leukotrienes are associated with hyperoxia-induced inhibition of alveolarization. We hypothesized that a 5-lipoxygenase-activating protein (FLAP) inhibitor given while newborn mice were exposed to 85% oxygen would prevent aberrant alveolarization in a dose- and time-dependent manner. Newborn mice were exposed to either room air or hyperoxia for 14 days. Pups were treated with either vehicle or MK-0591 10, 20, or 40 mg/kg subcutaneously daily for days 1-4, 5-9, or 10-14. On day 14, the lungs were inflated, fixed, and stained for histopathological and morphometric analyses. Hyperoxia groups treated with MK-0591 20 or 40 mg/kg during days P1-P4 or P10-P14 showed alveolarization that resembled that of room air controls while untreated hyperoxia groups showed definite evidence of aberrant alveolarization but no inflammation. In a hyperoxia-exposed newborn mice model, a FLAP inhibitor given during critical window periods may prevent aberration of alveolarization in a dose- and time-dependent manner.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93386
DOI
10.1007/s00408-010-9264-1
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김규언(Kim, Kyu Earn) ; 남궁란(Namgung, Ran) ; 박문성(Park, Moon Sung) ; 박민수(Park, Min Soo) ; 손명현(Son, Myung Hyun) ; 이철(Lee, Chul)
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Full Text
http://link.springer.com/article/10.1007%2Fs00408-010-9264-1
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