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Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women

 Moo-Young Kim  ;  Ji-Won Lee  ;  Hee-Cheol Kang  ;  Eosu Kim  ;  Duk-Chul Lee 
 Archives of Gerontology and Geriatics, Vol.53(2) : 218-221, 2011 
Journal Title
 Archives of Gerontology and Geriatics 
Issue Date
The purpose of this study was to investigate whether mitochondrial DNA (mtDNA) content of peripheral blood leukocyte is related to depression in community-dwelling old women. A total of 142 community-dwelling women, older than 60 years, were included in the study. The mtDNA copy number, which represents the mtDNA content, was measured using real-time PCR methods. Patients with depression defined as the subjects whose 15-question geriatric depression scale (GDS) score was ≥ 8 or who were taking anti-depressant medication. We also measured cognitive function, physical performances (gait speed, chair-stand times, tandem standing times) and metabolic parameters. The depression group had a significantly lower mtDNA copy number than the control group (71.5 vs. 107.3; interquartile range (IQR) = 42.7-116.0 vs. 51.7-202.1; p = 0.028). The Korean version of the mini mental state examination (K-MMSE) score and physical performance score were significantly lower in the depression group than in the control group (p = 0.041, and p = 0.002, respectively). After adjustment for confounding factors using multiple logistic regression analysis, mtDNA copy number was significantly related to depression (p = 0.025). We demonstrated that low leukocyte mtDNA content is related to depression in community dwelling old women. This finding suggests that mitochondrial dysfunction could be a mechanism of geriatric depression.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
Yonsei Authors
강희철(Kang, Hee Cheol) ; 김무영(Kim, Moo Young) ; 김어수(Kim, Eo Su) ; 이덕철(Lee, Duk Chul) ; 이지원(Lee, Ji Won)
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