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Leukocyte mitochondrial DNA (mtDNA) content is associated with depression in old women

Authors
 Moo-Young Kim  ;  Ji-Won Lee  ;  Hee-Cheol Kang  ;  Eosu Kim  ;  Duk-Chul Lee 
Citation
 ARCHIVES OF GERONTOLOGY AND GERIATRICS, Vol.53(2) : 218-221, 2011 
Journal Title
ARCHIVES OF GERONTOLOGY AND GERIATRICS
ISSN
 0167-4943 
Issue Date
2011
MeSH
Aged ; Cognition/physiology* ; DNA, Mitochondrial/blood* ; DNA, Mitochondrial/genetics ; Depression/blood ; Depression/genetics* ; Depression/physiopathology ; Female ; Humans ; Leukocytes/metabolism* ; Middle Aged ; Reverse Transcriptase Polymerase Chain Reaction
Keywords
Mitochondria ; Deoxyribonucleic acid ; Depression ; Geriatric psychiatry
Abstract
The purpose of this study was to investigate whether mitochondrial DNA (mtDNA) content of peripheral blood leukocyte is related to depression in community-dwelling old women. A total of 142 community-dwelling women, older than 60 years, were included in the study. The mtDNA copy number, which represents the mtDNA content, was measured using real-time PCR methods. Patients with depression defined as the subjects whose 15-question geriatric depression scale (GDS) score was ≥ 8 or who were taking anti-depressant medication. We also measured cognitive function, physical performances (gait speed, chair-stand times, tandem standing times) and metabolic parameters. The depression group had a significantly lower mtDNA copy number than the control group (71.5 vs. 107.3; interquartile range (IQR) = 42.7-116.0 vs. 51.7-202.1; p = 0.028). The Korean version of the mini mental state examination (K-MMSE) score and physical performance score were significantly lower in the depression group than in the control group (p = 0.041, and p = 0.002, respectively). After adjustment for confounding factors using multiple logistic regression analysis, mtDNA copy number was significantly related to depression (p = 0.025). We demonstrated that low leukocyte mtDNA content is related to depression in community dwelling old women. This finding suggests that mitochondrial dysfunction could be a mechanism of geriatric depression.
Full Text
http://www.sciencedirect.com/science/article/pii/S0167494310003092
DOI
10.1016/j.archger.2010.11.019
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Hee Cheol(강희철) ORCID logo https://orcid.org/0000-0002-0309-7448
Kim, Moo Young(김무영)
Kim, Eosu(김어수) ORCID logo https://orcid.org/0000-0001-9472-9465
Lee, Duk Chul(이덕철) ORCID logo https://orcid.org/0000-0001-9166-1813
Lee, Ji Won(이지원) ORCID logo https://orcid.org/0000-0002-2666-4249
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93384
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