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A multicenter study on extramammary Paget's disease in Korea

Authors
 Seok-Jong Lee  ;  Yoon Seok Choe  ;  Hong Dae Jung  ;  Sung Ku Ahn  ;  Young Chang Cha  ;  Kwang Hyun Cho  ;  Hae Young Choi  ;  Kee Yang Chung  ;  Chang Hun Huh  ;  Il Hwan Kim  ;  Ki-Ho Kim  ;  Moon Bum Kim  ;  Myung Hwa Kim  ;  You Chan Kim  ;  Jee Bum Lee  ;  Mi Woo Lee  ;  Min-Geol Lee  ;  Weon Ju Lee  ;  Dong Hoon Shin  ;  Jeong-Hyun Shin  ;  Kee Suck Suh  ;  Young Ho Won 
Citation
 INTERNATIONAL JOURNAL OF DERMATOLOGY, Vol.50(5) : 508-515, 2011 
Journal Title
INTERNATIONAL JOURNAL OF DERMATOLOGY
ISSN
 0011-9059 
Issue Date
2011
MeSH
Adult ; Aged ; Aged, 80 and over ; Colonic Neoplasms*/diagnosis ; Colonic Neoplasms*/epidemiology ; Colonic Neoplasms*/pathology ; Colonic Neoplasms*/surgery ; Female ; Humans ; Male ; Middle Aged ; Mohs Surgery/methods ; Multicenter Studies as Topic ; Neoplasm Recurrence, Local/surgery ; Paget Disease, Extramammary*/diagnosis ; Paget Disease, Extramammary*/epidemiology ; Paget Disease, Extramammary*/pathology ; Paget Disease, Extramammary*/surgery ; Rectal Neoplasms*/diagnosis ; Rectal Neoplasms*/epidemiology ; Rectal Neoplasms*/pathology ; Rectal Neoplasms*/surgery ; Republic ofKorea/epidemiology ; Retrospective Studies ; Sex Factors ; Stomach Neoplasms*/diagnosis ; Stomach Neoplasms*/epidemiology ; Stomach Neoplasms*/pathology ; Stomach Neoplasms*/surgery ; Treatment Outcome ; Young Adult
Abstract
BACKGROUND: There has been little research on extramammary Paget's disease (EMPD) conducted in Asia.

METHODS: The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period.

RESULTS: As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180 months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%).

CONCLUSIONS: In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-4632.2010.04661.x/abstract
DOI
10.1111/j.1365-4632.2010.04661.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Min Geol(이민걸) ORCID logo https://orcid.org/0000-0001-7040-5335
Chung, Kee Yang(정기양) ORCID logo https://orcid.org/0000-0003-3257-0297
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93339
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