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A multicenter study on extramammary Paget's disease in Korea

Authors
 Seok-Jong Lee  ;  Yoon Seok Choe  ;  Young Ho Won  ;  Kee Suck Suh  ;  Jeong-Hyun Shin  ;  Dong Hoon Shin  ;  Weon Ju Lee  ;  Min-Geol Lee  ;  Mi Woo Lee  ;  Jee Bum Lee  ;  You Chan Kim  ;  Myung Hwa Kim  ;  Moon Bum Kim  ;  Ki-Ho Kim  ;  Il Hwan Kim  ;  Chang Hun Huh  ;  Kee Yang Chung  ;  Hae Young Choi  ;  Kwang Hyun Cho  ;  Young Chang Cha  ;  Sung Ku Ahn  ;  Hong Dae Jung 
Citation
 International Journal of Dermatology, Vol.50(5) : 508-515, 2011 
Journal Title
 International Journal of Dermatology 
ISSN
 0011-9059 
Issue Date
2011
Abstract
BACKGROUND: There has been little research on extramammary Paget's disease (EMPD) conducted in Asia. METHODS: The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period. RESULTS: As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180 months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%). CONCLUSIONS: In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93339
DOI
10.1111/j.1365-4632.2010.04661.x
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
Yonsei Authors
이민걸(Lee, Min Geol) ; 정기양(Chung, Kee Yang)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1365-4632.2010.04661.x/abstract
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