Cited 65 times in
Differentiation of hepatic hyperintense lesions seen on gadoxetic acid-enhanced hepatobiliary phase MRI.
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김기황 | - |
dc.contributor.author | 김명진 | - |
dc.contributor.author | 박미숙 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 서영주 | - |
dc.contributor.author | 최진영 | - |
dc.date.accessioned | 2014-12-20T16:43:36Z | - |
dc.date.available | 2014-12-20T16:43:36Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0361-803X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/93261 | - |
dc.description.abstract | OBJECTIVE: The purpose of this study was to define imaging features that may help characterize hyperintense lesions seen in the hepatobiliary phase of gadoxetic acid-enhanced hepatic MRI examinations. MATERIALS AND METHODS: This retrospective study included 48 hyperintense nodules depicted on gadoxetic acid disodium-enhanced hepatobiliary phase MR images: 16 hepatocellular carcinomas (HCCs), 14 lesions of focal nodular hyperplasia, and 18 benign nodules associated with cirrhosis. Two observers independently reviewed hepatobiliary phase images and recorded the shape, margin, focal defects in contrast uptake, nodule-in-nodule pattern of uptake, central scar, internal septation, and presence of a hypointense rim around the lesion. Interobserver agreement was assessed with kappa statistics, and consensus opinions were reached by conference. For quantitative analysis, one observer measured lesion-to-liver contrast ratio (signal intensity of tumor divided by signal intensity of liver) on hepatobiliary phase images. Logistic regression analysis was used to determine the value of individual clinical and MR findings in prediction of malignancy. RESULTS: Compared with benign lesions, hyperintense HCC more commonly had focal defects in uptake (68.8% vs 3.1%, respectively; p < 0.001), nodule-in-nodule appearance (75.0% vs 0%, p < 0.001), absence of a central scar (100% vs 46.9%, p < 0.001), internal septation (50.0% vs 3.1%, p < 0.001), and a hypointense rim (75.0% vs 15.6%, p < 0.001) on hepatobiliary phase MR images. The mean contrast ratios of HCC (1.31) and benign lesions (1.28) were not significantly different (p = 0.63). Multiple logistic regression analysis showed that a focal defect in contrast uptake (p = 0.025) and a hypointense rim (p = 0.019) were significant predictors of HCC, having odds ratios of 36.8 (95% CI, 1.56-870.0) and 17.5 (1.60-191.4). CONCLUSION: On gadoxetic acid-enhanced MR images, hyperintense nodules can be differentiated with several imaging characteristics, especially a focal defect in contrast uptake and a hypointense rim, that indicate the diagnosis of hyperintense HCC. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF ROENTGENOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Hepatocellular/diagnosis* | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Diagnosis, Differential | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Focal Nodular Hyperplasia/diagnosis* | - |
dc.subject.MESH | Gadolinium DTPA* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Enhancement/methods* | - |
dc.subject.MESH | Liver Cirrhosis/diagnosis* | - |
dc.subject.MESH | Liver Neoplasms/diagnosis* | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.subject.MESH | Young Adult | - |
dc.title | Differentiation of hepatic hyperintense lesions seen on gadoxetic acid-enhanced hepatobiliary phase MRI. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Young Joo Suh | - |
dc.contributor.googleauthor | Myeong-Jin Kim | - |
dc.contributor.googleauthor | Jin-Young Choi | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Mi-Suk Park | - |
dc.contributor.googleauthor | Ki Whang Kim | - |
dc.identifier.doi | 10.2214/AJR.10.5845 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00345 | - |
dc.contributor.localId | A00426 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01892 | - |
dc.contributor.localId | A04200 | - |
dc.relation.journalcode | J00116 | - |
dc.identifier.eissn | 1546-3141 | - |
dc.identifier.pmid | 21700994 | - |
dc.identifier.url | http://www.ajronline.org/doi/abs/10.2214/AJR.10.5845 | - |
dc.subject.keyword | contrast material | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | MRI | - |
dc.subject.keyword | sensitivity | - |
dc.subject.keyword | specificity | - |
dc.contributor.alternativeName | Kim, Ki Whang | - |
dc.contributor.alternativeName | Kim, Myeong Jin | - |
dc.contributor.alternativeName | Park, Mi Sook | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Suh, Young Joo | - |
dc.contributor.alternativeName | Choi, Jin Young | - |
dc.contributor.affiliatedAuthor | Kim, Ki Whang | - |
dc.contributor.affiliatedAuthor | Kim, Myeong Jin | - |
dc.contributor.affiliatedAuthor | Park, Mi-Suk | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Suh, Young Joo | - |
dc.contributor.affiliatedAuthor | Choi, Jin Young | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 197 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | W44 | - |
dc.citation.endPage | W52 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF ROENTGENOLOGY, Vol.197(1) : W44-W52, 2011 | - |
dc.identifier.rimsid | 27100 | - |
dc.type.rims | ART | - |
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