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Epidermolysis bullosa acquisita: a retrospective clinical analysis of 30 cases

Authors
 Jong Hoon Kim ; Yeon Hee Kim ; Soo-Chan Kim 
Citation
 Acta Dermato-Venereologica , Vol.91(3) : 307~312, 2011 
Journal Title
 Acta Dermato-Venereologica 
ISSN
 0001-5555 
Issue Date
2011
Abstract
Epidermolysis bullosa acquisita (EBA) is an acquired, autoimmune blistering disorder caused by autoantibody production against type VII collagen. The aim of this study was to examine the clinical types, treatments, and outcomes of 30 patients with EBA. In our cohort, the median age of onset was 44.0 years, with a similar incidence for both genders (46.7% male, 53.3% female). The majority of patients had classic type (36.7%) and bullous pemphigoid (BP)-like type (46.7%) EBA. The remaining patients had mucous membrane pemphigoid-like (6.7%), Brunsting-Perry pemphigoid-like (6.7%), and linear IgA bullous dermatosis-like type (3.3%) EBA. All patients were treated initially with a combination of methylprednisolone, dapsone and colchicine. No significant differences in time to remission were identified between patients with classic vs. BP-like EBA. In a second subset analysis of 19 patients, a group treated with high-dose (> 8 mg) methylprednisolone achieved remission earlier (median time to remission: 3 months) than a group treated with low-dose (≤ 8 mg) methylprednisolone (median time to remission: 12 months), irrespective of clinical type (p = 0.003).
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/93256
DOI
10.2340/00015555-1065
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Dermatology
Yonsei Authors
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