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Anti-alpha-enolase antibody as a serologic marker and its correlation with disease severity in intestinal Behçet's disease.

 Sung Jae Shin  ;  Byung Chang Kim  ;  Won Ho Kim  ;  Kwang Hoon Lee  ;  Sang Kil Lee  ;  Tae Il Kim 
 Digestive Diseases and Sciences, Vol.56(3) : 812-818, 2011 
Journal Title
 Digestive Diseases and Sciences 
Issue Date
BACKGROUND: Intestinal Behçet's disease (BD) is a chronic inflammatory bowel disease, as are Crohn's disease (CD) and ulcerative colitis (UC). But unlike CD and UC, serologic markers for intestinal BD are not well known. Recently, anti-α-enolase antibody (AAEA) has been detected in sera from BD patients. AIMS: The aim of this study was to evaluate the prevalence of AAEA in intestinal BD and its clinical correlations. METHODS: The study sample included 80 patients with intestinal BD and 23 healthy controls. IgM AAEA was detected by ELISA. The positivity of IgM AAEA was defined as an optical density greater than three standard deviations above the mean of the control sera. Other parameters, such as demographic information, subtype of BD, colonoscopic findings, disease severity and treatment modality, were analyzed retrospectively. RESULTS: The prevalence of IgM AAEA was 67.5% in intestinal BD and 0% in the control group. The positivity rate of IgM AAEA was higher in complete or incomplete BD than in suspected BD (77.5% vs. 51.6%, P = 0.016). The mean HBI score was higher in antibody positive patients than in antibody negative patients (5.60 vs. 4.61, P = 0.003). The cumulative probability of steroid use for aggravation of intestinal and extra-intestinal symptoms was higher in antibody positive patients than in antibody negative patients (P = 0.012). The number of patients with systemic involvement was higher in the AAEA positive group than in the negative group. CONCLUSIONS: Monitoring IgM AAEA may be helpful for diagnosis of intestinal BD and could be used to predict clinical course and disease severity.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김병창(Kim, Byung Chang) ; 김원호(Kim, Won Ho) ; 김태일(Kim, Tae Il) ; 신성재(Shin, Sung Jae) ; 이광훈(Lee, Kwang Hoon) ; 이상길(Lee, Sang Kil)
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