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Tumor margin histology predicts tumor aggressiveness in papillary thyroid carcinoma: a study of 514 consecutive patients

Authors
 Kuk-Jin Kim  ;  Soon Won Hong  ;  Yong Sang Lee  ;  Bup-Woo Kim  ;  Seung Chul Lee  ;  Hang-Seok Chang  ;  Cheong Soo Park 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.26(3) : 346-351, 2011 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2011
MeSH
Adult ; Carcinoma ; Carcinoma, Papillary ; Cell Proliferation ; Female ; Humans ; Lymphatic Metastasis ; Male ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; Thyroid Neoplasms/epidemiology ; Thyroid Neoplasms/pathology*
Keywords
Aggressiveness ; Carcinoma, Papillary ; Histology ; Margin ; Thyroid
Abstract
Histologic patterns at tumor margins may be related to prognosis in several malignancies. We investigated tumor aggressiveness with respect to tumor margin histology in patients with papillary thyroid carcinoma (PTC). Five hundred fourteen consecutive patients who underwent surgery for primary PTC between January and July 2009 were assigned to two groups, one with an infiltrative pattern (I-type, n = 347) at tumor margins and one with an expanding pattern (E-type, n = 167). Tumor aggressiveness was assessed by analyzing relationships between these patterns and known prognostic factors. The analysis showed that unfavorable prognostic factors such as tumor multiplicity (P = 0.002), extrathyroidal extension (P < 0.001), lateral neck lymph node metastasis (P < 0.001) and advanced TNM stage (P = 0.001) were significantly more prevalent in patients with I-type PTC than in those with the E-type. Central neck node metastases were more prevalent without statistical significance in the I-type patients (P = 0.376). Tumor margin histology was not related to gender or tumor size. These results suggest that histologic patterns at tumor margins predict aggressiveness in PTC.
Files in This Item:
T201101373.pdf Download
DOI
10.3346/jkms.2011.26.3.346
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kuk Jin(김국진)
Kim, Bup Woo(김법우) ORCID logo https://orcid.org/0000-0002-1342-9055
Park, Cheong Soo(박정수)
Lee, Seung Chul(이승철)
Lee, Yong Sang(이용상) ORCID logo https://orcid.org/0000-0002-8234-8718
Chang, Hang Seok(장항석) ORCID logo https://orcid.org/0000-0002-5162-103X
Hong, Soon Won(홍순원) ORCID logo https://orcid.org/0000-0002-0324-2414
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93185
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