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Tumor margin histology predicts tumor aggressiveness in papillary thyroid carcinoma: a study of 514 consecutive patients

Authors
 Kuk-Jin Kim  ;  Soon Won Hong  ;  Cheong Soo Park  ;  Hang-Seok Chang  ;  Seung Chul Lee  ;  Bup-Woo Kim  ;  Yong Sang Lee 
Citation
 Journal of Korean Medical Science, Vol.26(3) : 346-351, 2011 
Journal Title
 Journal of Korean Medical Science 
ISSN
 1011-8934 
Issue Date
2011
Abstract
Histologic patterns at tumor margins may be related to prognosis in several malignancies. We investigated tumor aggressiveness with respect to tumor margin histology in patients with papillary thyroid carcinoma (PTC). Five hundred fourteen consecutive patients who underwent surgery for primary PTC between January and July 2009 were assigned to two groups, one with an infiltrative pattern (I-type, n = 347) at tumor margins and one with an expanding pattern (E-type, n = 167). Tumor aggressiveness was assessed by analyzing relationships between these patterns and known prognostic factors. The analysis showed that unfavorable prognostic factors such as tumor multiplicity (P = 0.002), extrathyroidal extension (P < 0.001), lateral neck lymph node metastasis (P < 0.001) and advanced TNM stage (P = 0.001) were significantly more prevalent in patients with I-type PTC than in those with the E-type. Central neck node metastases were more prevalent without statistical significance in the I-type patients (P = 0.376). Tumor margin histology was not related to gender or tumor size. These results suggest that histologic patterns at tumor margins predict aggressiveness in PTC.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/93185
DOI
10.3346/jkms.2011.26.3.346
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
김국진(Kim, Kuk Jin) ; 김법우(Kim, Bup Woo) ; 박정수(Park, Cheong Soo) ; 이승철(Lee, Seung Chul) ; 이용상(Lee, Yong Sang) ; 장항석(Chang, Hang Seok) ; 홍순원(Hong, Soon Won)
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