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Clinical experiences of pheochromocytoma in Korea

 Kwang Hyun Kim  ;  Jae Seung Chung  ;  Won Tae Kim  ;  Cheol Kyu Oh  ;  Yun Byung Chae  ;  Ho Song Yu  ;  Won Sik Ham  ;  Young Deuk Choi 
 YONSEI MEDICAL JOURNAL, Vol.52(1) : 45-50, 2011 
Journal Title
Issue Date
Adolescent ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/pathology ; Adult ; Aged ; Child ; Female ; Humans ; Male ; Middle Aged ; Pheochromocytoma/diagnosis* ; Pheochromocytoma/pathology ; Young Adult
Pheochromocytoma ; incidentaloma ; adrenal tumor
PURPOSE: We report herein 119 patients with pheochromocytoma at our institute over the last 23 years.

MATERIALS AND METHODS: Between 1986 and 2009, 119 patients were diagnosed with pheochromocytoma at our institute. We reviewed the medical records of these patients.

RESULTS: Of 119 patients, 45 were male and 74 were female, and mean age was 43.83 ± 13.49 years. Forty-three patients (36.1%) were diagnosed incidentally, and 8 patients (6.7%) were found to have familial pheochromocytoma. The mean dimension of the tumors was 5.89 ± 3.18 cm. 4 patients had bilateral tumors; three of these patients were found to have familial pheochromocytoma and 1 patient was diagnosed with malignant pheochromocytoma. A total of eight patients (6.7%) were found to have malignant pheochromocytoma. In 1 patient, metastasis to a lymph node was found at the time of diagnosis. Metastases were found at a mean of 49 ± 25.83 (6-75) months after surgery in the other seven patients. 6 patients died of malignant pheochromocytoma at a mean of 31 ± 28.71 months (1-81) after diagnosis, and the other 2 patients survived for 15 and 24 months, respectively.

CONCLUSION: Approximately 35% of patients with pheochromocytoma are diagnosed incidentally, and the number of detected cases is increasing. Although familial pheochromocytoma was found only in 6.7% of the patients, genetic testing should be considered in all patients, especially in patients with a family history, young age, or multifocal, bilateral, extra-adrenal, or malignant tumors. Given that malignant pheochromocytomas are frequently diagnosed during the follow-up period, long-term follow-up is necessary to confirm the absence of recurrence or metastasis
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Yu, Ho Song(유호송)
Chae, Yun Byung(채윤병)
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Ham, Won Sik(함원식) ORCID logo https://orcid.org/0000-0003-2246-8838
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