54 103

Cited 0 times in

Polymorphisms in the intermediate region of VacA impact Helicobacter pylori-induced disease development

 Kathleen R. Jones  ;  Sungil Jang  ;  Jeong-Heon Cha  ;  D. Scott Merrell  ;  Cara H. Olsen  ;  In-Sik Chung  ;  Jinmoon Kim  ;  Jennifer Y. Chang 
 Journal of Clinical Microbiology, Vol.49(1) : 101-110, 2011 
Journal Title
 Journal of Clinical Microbiology 
Issue Date
Helicobacter pylori is the etiological agent of diseases such as gastritis, gastric and duodenal ulcers, and two types of gastric cancers. While some insight has been gained into the etiology of these diverse manifestations, by and large, the reason that some individuals develop more severe disease remains elusive. Recent studies have focused on the roles of H. pylori toxins CagA and VacA on the disease process and have suggested that both toxins are intimately involved. Moreover, CagA and VacA are polymorphic within different H. pylori strains, and particular polymorphisms seem to show a correlation with the development of particular disease states. Among VacA polymorphisms, the intermediate region has recently been proposed to play a major role in disease outcome. In this article, we describe a detailed sequence analysis of the polymorphic intermediate region of vacA from strains obtained from a large South Korean population. We show that polymorphisms found at amino acid position 196 are associated with more severe disease manifestations. Additionally, polymorphisms found at amino acid position 231 are linked to disease in strains that carry the non-EPIYA-ABD allele of CagA. Collectively, these data help explain the impact of the VacA intermediate region on disease and lead to the hypothesis that there are allele-driven interactions between VacA and CagA.
Appears in Collections:
1. Journal Papers (연구논문) > 2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실)
Yonsei Authors
김진문(Kim, Jin Moon) ; 장성일(Jang, Sung Il) ; 차정헌(Cha, Jung Heon)
사서에게 알리기
Files in This Item:
T201101210.pdf Download
RIS (EndNote)
XLS (Excel)


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.