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Drug-loaded porous spherical hydroxyapatite granules for bone regeneration

Authors
 Min-Ho Hong  ;  Jun-Sik Son  ;  Kwang-Mahn Kim  ;  Myungho Han  ;  Daniel S. Oh  ;  Yong-Keun Lee 
Citation
 JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol.22(2) : 349-355, 2011 
Journal Title
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
ISSN
 0957-4530 
Issue Date
2011
MeSH
Bone Regeneration* ; Bone Substitutes/chemistry ; Bone and Bones/metabolism ; Dexamethasone/administration & dosage ; Drug Carriers ; Drug Delivery Systems ; Durapatite/chemistry* ; Humans ; Microscopy, Electron, Scanning/methods ; Nanotechnology/methods ; Porosity ; Powders ; Sodium Chloride/chemistry ; Spectrophotometry, Ultraviolet/methods
Keywords
Drug Release ; Pore Volume ; Protein Drug ; Drug Release Behavior ; Spherical Granule
Abstract
Porous spherical hydroxyapatite (HAp) granules, which are not only can be used for bone void filler, but also drug delivery systems, were prepared using a liquid nitrogen method. Various pore and channel structures of spherical granules were obtained by adjusting the ratio of water to HAp powder and the amount of sodium chloride (NaCl). By using the water to powder ratio at 2.0 ml/g and the amount of NaCl at 15 wt% by powder, the spherical granules have optimal pore volume, micro-channel structure and strength to handle as well as the ability to work as a drug delivery system. When the NaCl content was 15 wt%, the micro-channel structure was changed, but the pore volume was maintained. For the drug release test, dexamathasone (Dex) was loaded as a model drug on the prepared HAp granules by the immersion method, and the drug release behavior was curved by a UV/vis spectrophotometer. As a result, different drug release behavior was observed according to micro-channel structural differences. Therefore, it was concluded that the NACl could be applied as the pore and micro-channel structure control agent. Porous spherical HAp granules, which were fabricated by a liquid nitrogen method, show potential as bone void filler with the ability of controlled drug release
Full Text
http://link.springer.com/article/10.1007%2Fs10856-010-4197-z
DOI
10.1007/s10856-010-4197-z
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Lee, Yong Keun(이용근)
Hong, Min Ho(홍민호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92946
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