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Drug-loaded porous spherical hydroxyapatite granules for bone regeneration

DC Field Value Language
dc.contributor.author김광만-
dc.contributor.author이용근-
dc.contributor.author홍민호-
dc.date.accessioned2014-12-20T16:33:36Z-
dc.date.available2014-12-20T16:33:36Z-
dc.date.issued2011-
dc.identifier.issn0957-4530-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92946-
dc.description.abstractPorous spherical hydroxyapatite (HAp) granules, which are not only can be used for bone void filler, but also drug delivery systems, were prepared using a liquid nitrogen method. Various pore and channel structures of spherical granules were obtained by adjusting the ratio of water to HAp powder and the amount of sodium chloride (NaCl). By using the water to powder ratio at 2.0 ml/g and the amount of NaCl at 15 wt% by powder, the spherical granules have optimal pore volume, micro-channel structure and strength to handle as well as the ability to work as a drug delivery system. When the NaCl content was 15 wt%, the micro-channel structure was changed, but the pore volume was maintained. For the drug release test, dexamathasone (Dex) was loaded as a model drug on the prepared HAp granules by the immersion method, and the drug release behavior was curved by a UV/vis spectrophotometer. As a result, different drug release behavior was observed according to micro-channel structural differences. Therefore, it was concluded that the NACl could be applied as the pore and micro-channel structure control agent. Porous spherical HAp granules, which were fabricated by a liquid nitrogen method, show potential as bone void filler with the ability of controlled drug release-
dc.description.statementOfResponsibilityopen-
dc.format.extent349~355-
dc.relation.isPartOfJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHBone Regeneration*-
dc.subject.MESHBone Substitutes/chemistry-
dc.subject.MESHBone and Bones/metabolism-
dc.subject.MESHDexamethasone/administration & dosage-
dc.subject.MESHDrug Carriers-
dc.subject.MESHDrug Delivery Systems-
dc.subject.MESHDurapatite/chemistry*-
dc.subject.MESHHumans-
dc.subject.MESHMicroscopy, Electron, Scanning/methods-
dc.subject.MESHNanotechnology/methods-
dc.subject.MESHPorosity-
dc.subject.MESHPowders-
dc.subject.MESHSodium Chloride/chemistry-
dc.subject.MESHSpectrophotometry, Ultraviolet/methods-
dc.titleDrug-loaded porous spherical hydroxyapatite granules for bone regeneration-
dc.typeArticle-
dc.contributor.collegeCollege of Dentistry (치과대학)-
dc.contributor.departmentDept. of Dental Engineering (치과생체재료공학)-
dc.contributor.googleauthorMin-Ho Hong-
dc.contributor.googleauthorJun-Sik Son-
dc.contributor.googleauthorKwang-Mahn Kim-
dc.contributor.googleauthorMyungho Han-
dc.contributor.googleauthorDaniel S. Oh-
dc.contributor.googleauthorYong-Keun Lee-
dc.identifier.doi10.1007/s10856-010-4197-z-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00312-
dc.contributor.localIdA02976-
dc.contributor.localIdA04392-
dc.relation.journalcodeJ01576-
dc.identifier.eissn1573-4838-
dc.identifier.pmid21222142-
dc.identifier.urlhttp://link.springer.com/article/10.1007%2Fs10856-010-4197-z-
dc.subject.keywordDrug Release-
dc.subject.keywordPore Volume-
dc.subject.keywordProtein Drug-
dc.subject.keywordDrug Release Behavior-
dc.subject.keywordSpherical Granule-
dc.contributor.alternativeNameKim, Kwang Mahn-
dc.contributor.alternativeNameLee, Yong Keun-
dc.contributor.alternativeNameHong, Min Ho-
dc.contributor.affiliatedAuthorKim, Kwang Mahn-
dc.contributor.affiliatedAuthorLee, Yong Keun-
dc.contributor.affiliatedAuthorHong, Min Ho-
dc.rights.accessRightsnot free-
dc.citation.volume22-
dc.citation.number2-
dc.citation.startPage349-
dc.citation.endPage355-
dc.identifier.bibliographicCitationJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, Vol.22(2) : 349-355, 2011-
dc.identifier.rimsid27921-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers

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