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Bcl-XL prevents serum deprivation-induced oxidative stress mediated by Romo1

Authors
 Seung Baek Lee  ;  Hyung Jung Kim  ;  Jungar Shin  ;  Sung Tae Kang  ;  Seongman Kang  ;  Young Do Yoo 
Citation
 ONCOLOGY REPORTS, Vol.25(5) : 1337-1342, 2011 
Journal Title
ONCOLOGY REPORTS
ISSN
 1021-335X 
Issue Date
2011
MeSH
Apoptosis/physiology ; Cell Line ; Gene Expression Regulation, Neoplastic ; HEK293 Cells ; HeLa Cells ; Humans ; Membrane Proteins/metabolism* ; Mitochondrial Proteins/metabolism* ; Oxidative Stress* ; Reactive Oxygen Species/metabolism ; Serum/metabolism* ; bcl-X Protein/genetics ; bcl-X Protein/metabolism*
Abstract
B-cell lymphoma-extra large (Bcl-XL) has been known to suppress serum deprivation-induced cell death, while reactive oxygen species modulator 1 (Romo1) is responsible for a serum deprivation-induced increase in reactive oxygen species (ROS). Therefore, we investigated whether Bcl-XL expression could inhibit the serum deprivation-induced increase in ROS and cell death, which are mediated by Romo1. We found that Bcl-XL expression effectively blocked serum deprivation- and Romo1-triggered ROS generation. Bcl-XL also inhibited apoptotic cell death induced by both serum deprivation and oxidative stress. From these results, we suggest that increased Bcl-XL expression, which is observed in many cancer cells, confers resistance to oxidative stress in the cancer cells by suppressing Romo1-mediated oxidative stress
Full Text
http://www.spandidos-publications.com/or/25/5/1337
DOI
10.3892/or.2011.1210
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyung Jung(김형중) ORCID logo https://orcid.org/0000-0003-2498-0683
Shin, Jung Ar(신정아)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92910
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