Cited 13 times in
Bcl-XL prevents serum deprivation-induced oxidative stress mediated by Romo1
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김형중 | - |
dc.contributor.author | 신정아 | - |
dc.date.accessioned | 2014-12-20T16:32:24Z | - |
dc.date.available | 2014-12-20T16:32:24Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92910 | - |
dc.description.abstract | B-cell lymphoma-extra large (Bcl-XL) has been known to suppress serum deprivation-induced cell death, while reactive oxygen species modulator 1 (Romo1) is responsible for a serum deprivation-induced increase in reactive oxygen species (ROS). Therefore, we investigated whether Bcl-XL expression could inhibit the serum deprivation-induced increase in ROS and cell death, which are mediated by Romo1. We found that Bcl-XL expression effectively blocked serum deprivation- and Romo1-triggered ROS generation. Bcl-XL also inhibited apoptotic cell death induced by both serum deprivation and oxidative stress. From these results, we suggest that increased Bcl-XL expression, which is observed in many cancer cells, confers resistance to oxidative stress in the cancer cells by suppressing Romo1-mediated oxidative stress | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1337~1342 | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Apoptosis/physiology | - |
dc.subject.MESH | Cell Line | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | HEK293 Cells | - |
dc.subject.MESH | HeLa Cells | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Membrane Proteins/metabolism* | - |
dc.subject.MESH | Mitochondrial Proteins/metabolism* | - |
dc.subject.MESH | Oxidative Stress* | - |
dc.subject.MESH | Reactive Oxygen Species/metabolism | - |
dc.subject.MESH | Serum/metabolism* | - |
dc.subject.MESH | bcl-X Protein/genetics | - |
dc.subject.MESH | bcl-X Protein/metabolism* | - |
dc.title | Bcl-XL prevents serum deprivation-induced oxidative stress mediated by Romo1 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Seung Baek Lee | - |
dc.contributor.googleauthor | Hyung Jung Kim | - |
dc.contributor.googleauthor | Jungar Shin | - |
dc.contributor.googleauthor | Sung Tae Kang | - |
dc.contributor.googleauthor | Seongman Kang | - |
dc.contributor.googleauthor | Young Do Yoo | - |
dc.identifier.doi | 10.3892/or.2011.1210 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01158 | - |
dc.contributor.localId | A02146 | - |
dc.relation.journalcode | J02419 | - |
dc.identifier.eissn | 1791-2431 | - |
dc.identifier.pmid | 21399876 | - |
dc.identifier.url | http://www.spandidos-publications.com/or/25/5/1337 | - |
dc.contributor.alternativeName | Kim, Hyung Jung | - |
dc.contributor.alternativeName | Shin, Jung Ar | - |
dc.contributor.affiliatedAuthor | Kim, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Shin, Jung Ar | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 1337 | - |
dc.citation.endPage | 1342 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, Vol.25(5) : 1337-1342, 2011 | - |
dc.identifier.rimsid | 27894 | - |
dc.type.rims | ART | - |
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