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Alanine aminotransferase is associated with metabolic syndrome independently of insulin resistance.

Authors
 Ji Eun Yun  ;  Sang Yeun Kim  ;  Sun Ha Jee  ;  Heejin Kimm  ;  Sun Ju Lee  ;  Hee-Cheol Kang 
Citation
 Circulation Journal, Vol.75(4) : 964-969, 2011 
Journal Title
 Circulation Journal 
ISSN
 1346-9843 
Issue Date
2011
Abstract
BACKGROUND: Few studies have examined the effect of insulin resistance on the association between alanine aminotransferase (ALT) and metabolic syndrome. The association between ALT levels and metabolic syndrome were determined, independently of insulin resistance in Korean populations. METHODS AND RESULTS: The association between ALT and metabolic syndrome were examined in 28,456 subjects who visited 7 Health Promotion Centers at University Hospitals in Korea from 2006 to 2008. HOMA-IR index was used to represent insulin resistance index. ALT levels were found to be positively associated with metabolic syndrome after adjusting for age, alcohol intake, and smoking status. Furthermore, when additional adjustment was made for insulin resistance, this association between ALT and metabolic syndrome, although slightly attenuated, remained strongly significant. Subjects in the highest ALT quartile were found to have a higher risk of having metabolic syndrome than those in the lowest quartile (odds ratio (OR)=4.45, 95% confidence interval (CI)=3.96-4.99 for men and OR=3.51, 95%CI=2.73-4.52 for women). In addition, the association between ALT level and the risk of metabolic syndrome was significantly higher in the relatively low risk group. CONCLUSIONS: ALT levels were found to be significantly associated with metabolic syndrome independently of insulin resistance and with an interaction by age. Further cohort studies are needed to determine the usefulness of ALT levels for predicting the risk of metabolic syndrome. All rights are reserved to the Japanese Circulation Society.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92780
DOI
10.1253/circj.CJ-10-0465
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실)
1. Journal Papers (연구논문) > 4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원)
Yonsei Authors
강희철(Kang, Hee Cheol) ; 김희진(Kimm, Hee Jin) ; 윤지은(Yun, Ji Eun) ; 이선주(Lee, Sun Ju) ; 지선하(Jee, Sun Ha)
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