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Alanine aminotransferase is associated with metabolic syndrome independently of insulin resistance.

 Ji Eun Yun  ;  Sang Yeun Kim  ;  Hee-Cheol Kang  ;  Sun Ju Lee  ;  Heejin Kimm  ;  Sun Ha Jee 
 CIRCULATION JOURNAL, Vol.75(4) : 964-969, 2011 
Journal Title
Issue Date
Adult ; Age Factors ; Alanine Transaminase/blood* ; Asian Continental Ancestry Group ; Female ; Humans ; Insulin Resistance* ; Korea/epidemiology ; Male ; Metabolic Syndrome/blood* ; Metabolic Syndrome/epidemiology ; Middle Aged ; Risk Factors
Alanine aminotransferase ; Insulin resistance ; Metabolic syndrome
BACKGROUND: Few studies have examined the effect of insulin resistance on the association between alanine aminotransferase (ALT) and metabolic syndrome. The association between ALT levels and metabolic syndrome were determined, independently of insulin resistance in Korean populations. METHODS AND RESULTS: The association between ALT and metabolic syndrome were examined in 28,456 subjects who visited 7 Health Promotion Centers at University Hospitals in Korea from 2006 to 2008. HOMA-IR index was used to represent insulin resistance index. ALT levels were found to be positively associated with metabolic syndrome after adjusting for age, alcohol intake, and smoking status. Furthermore, when additional adjustment was made for insulin resistance, this association between ALT and metabolic syndrome, although slightly attenuated, remained strongly significant. Subjects in the highest ALT quartile were found to have a higher risk of having metabolic syndrome than those in the lowest quartile (odds ratio (OR)=4.45, 95% confidence interval (CI)=3.96-4.99 for men and OR=3.51, 95%CI=2.73-4.52 for women). In addition, the association between ALT level and the risk of metabolic syndrome was significantly higher in the relatively low risk group. CONCLUSIONS: ALT levels were found to be significantly associated with metabolic syndrome independently of insulin resistance and with an interaction by age. Further cohort studies are needed to determine the usefulness of ALT levels for predicting the risk of metabolic syndrome. All rights are reserved to the Japanese Circulation Society.
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1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kang, Hee Cheol(강희철) ORCID logo https://orcid.org/0000-0002-0309-7448
Kimm, Heejin(김희진) ORCID logo https://orcid.org/0000-0003-4526-0570
Yun, Ji Eun(윤지은)
Lee, Sun Ju(이선주) ORCID logo https://orcid.org/0000-0002-6582-8795
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
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