Cited 78 times in
Specific Near-IR Absorption Imaging of Glioblastomas Using Integrin-Targeting Gold Nanorods
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서진석 | - |
dc.contributor.author | 양재문 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2014-12-20T16:28:18Z | - |
dc.date.available | 2014-12-20T16:28:18Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92778 | - |
dc.description.abstract | Molecular imaging using nanoprobes with high resolution and low toxicity is essential in early cancer detection. Here we introduce a new class of smart imaging probes employing PEGylated gold nanorods (GNRs) conjugated to cRGD for specific optical imaging of vβ3 integrins from glioblastoma. GNRs exhibiting an optical resonance peak in the near-infrared (NIR) region were synthesized using the seed-mediated growth method. CTAB (cetyl trimethylammonium bromide) bilayer on the GNRs was replaced with a biocompatible stabilizer, heterobifunctional polyethyleneglycol (COOH-PEG-SH). Further, the carboxylated GNRs (PGNRs; PEG-coated GNRs) were functionalized with cRGD using EDC-NHS chemistry to formulate cRGD-conjugated GNRs (cRGD-PGNRs) for vβ3 integrins. In order to assess the potential of the cRGD-PGNRs as a targeted imaging probe, we investigated their optical properties, biocompatibility, colloidal stability and in vitro/in vivo binding affinities for cancer cells. Consequently, cRGD-PGNRs demonstrated excellent tumor targeting ability with no cytotoxicity, as well as sufficient cellular uptake due to stable and prolonged blood circulation of cRGD-PGNRs. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 1082~1088 | - |
dc.relation.isPartOf | ADVANCED FUNCTIONAL MATERIALS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Specific Near-IR Absorption Imaging of Glioblastomas Using Integrin-Targeting Gold Nanorods | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Jihye Choi | - |
dc.contributor.googleauthor | Jaemoon Yang | - |
dc.contributor.googleauthor | Joseph Park | - |
dc.contributor.googleauthor | Eunjung Kim | - |
dc.contributor.googleauthor | Jin-Suck Suh | - |
dc.contributor.googleauthor | Yong-Min Huh | - |
dc.contributor.googleauthor | Seungjoo Haam | - |
dc.identifier.doi | 10.1002/adfm.201002253 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02315 | - |
dc.contributor.localId | A01916 | - |
dc.contributor.localId | A04359 | - |
dc.relation.journalcode | J00041 | - |
dc.identifier.eissn | 1616-3028 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/adfm.201002253/abstract | - |
dc.contributor.alternativeName | Suh, Jin Suck | - |
dc.contributor.alternativeName | Yang, Jae Moon | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Yang, Jae Moon | - |
dc.contributor.affiliatedAuthor | Suh, Jin Suck | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 21 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1082 | - |
dc.citation.endPage | 1088 | - |
dc.identifier.bibliographicCitation | ADVANCED FUNCTIONAL MATERIALS, Vol.21(6) : 1082-1088, 2011 | - |
dc.identifier.rimsid | 28754 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.