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DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma.

Authors
 Wook Jin ; Jong-Joo Lee ; Hyoung-Pyo Kim ; Yong Kyun Cho ; Byung Ho Son ; Min Soo Kim 
Citation
 Biochemical and Biophysicial Research Communications, Vol.406(1) : 89~95, 2011 
Journal Title
 Biochemical and Biophysicial Research Communications 
ISSN
 0006-291X 
Issue Date
2011
Abstract
The tropomyosin-related kinase (Trk) family of neurotrophin receptors, TrkA, TrkB and TrkC, has been implicated in the growth and survival of human cancers. Here we report that Trks are frequently overexpressed in hepatocellular carcinoma (HCC) from patients and human liver cancer cell lines. To unravel the underlying molecular mechanism(s) for this phenomenon, DNA methylation patterns of CpG islands in TrkA, TrkB, and TrkC genes were examined in normal and cancer cell lines derived from liver. A good correlation was observed between promoter hypermethylation and lower expression of TrkA, TrkB, and TrkC genes, which was supported by the data that inhibiting DNA methylation with 5-azacytidine restored expression of those genes in normal liver cell lines. Furthermore, Trks promoted the proliferation of HepG2 and induced expression of the metastatic regulator, Twist. These results suggest that Trks may contribute to growth and metastasis of liver cancer.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92769
DOI
10.1016/j.bbrc.2011.01.116
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Environmental Medical Biology
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0006291X11001689
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