Cited 29 times in
DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma.
DC Field | Value | Language |
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dc.contributor.author | 김형표 | - |
dc.contributor.author | 이종주 | - |
dc.date.accessioned | 2014-12-20T16:28:00Z | - |
dc.date.available | 2014-12-20T16:28:00Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92769 | - |
dc.description.abstract | The tropomyosin-related kinase (Trk) family of neurotrophin receptors, TrkA, TrkB and TrkC, has been implicated in the growth and survival of human cancers. Here we report that Trks are frequently overexpressed in hepatocellular carcinoma (HCC) from patients and human liver cancer cell lines. To unravel the underlying molecular mechanism(s) for this phenomenon, DNA methylation patterns of CpG islands in TrkA, TrkB, and TrkC genes were examined in normal and cancer cell lines derived from liver. A good correlation was observed between promoter hypermethylation and lower expression of TrkA, TrkB, and TrkC genes, which was supported by the data that inhibiting DNA methylation with 5-azacytidine restored expression of those genes in normal liver cell lines. Furthermore, Trks promoted the proliferation of HepG2 and induced expression of the metastatic regulator, Twist. These results suggest that Trks may contribute to growth and metastasis of liver cancer. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 89~95 | - |
dc.relation.isPartOf | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Antimetabolites, Antineoplastic/pharmacology | - |
dc.subject.MESH | Azacitidine/pharmacology | - |
dc.subject.MESH | Base Sequence | - |
dc.subject.MESH | Carcinoma, Hepatocellular/genetics* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Cell Proliferation | - |
dc.subject.MESH | DNA Methylation* | - |
dc.subject.MESH | Gene Expression Regulation, Enzymologic* | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver Neoplasms/genetics* | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Nuclear Proteins/genetics | - |
dc.subject.MESH | Promoter Regions, Genetic | - |
dc.subject.MESH | Receptor, trkA/genetics* | - |
dc.subject.MESH | Receptor, trkB/genetics* | - |
dc.subject.MESH | Receptor, trkC/genetics* | - |
dc.subject.MESH | Receptors, Nerve Growth Factor/genetics | - |
dc.subject.MESH | Twist-Related Protein 1/genetics | - |
dc.title | DNA methylation-dependent regulation of TrkA, TrkB, and TrkC genes in human hepatocellular carcinoma. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Environmental Medical Biology (환경의생물학) | - |
dc.contributor.googleauthor | Wook Jin | - |
dc.contributor.googleauthor | Jong-Joo Lee | - |
dc.contributor.googleauthor | Min Soo Kim | - |
dc.contributor.googleauthor | Byung Ho Son | - |
dc.contributor.googleauthor | Yong Kyun Cho | - |
dc.contributor.googleauthor | Hyoung-Pyo Kim | - |
dc.identifier.doi | 10.1016/j.bbrc.2011.01.116 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01163 | - |
dc.contributor.localId | A03148 | - |
dc.relation.journalcode | J00281 | - |
dc.identifier.eissn | 1090-2104 | - |
dc.identifier.pmid | 21295543 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0006291X11001689 | - |
dc.subject.keyword | Trk | - |
dc.subject.keyword | Hepatocellular carcinoma | - |
dc.subject.keyword | DNA methylation | - |
dc.subject.keyword | Twist | - |
dc.contributor.alternativeName | Kim, Hyoung Pyo | - |
dc.contributor.alternativeName | Lee, Jong Joo | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Pyo | - |
dc.contributor.affiliatedAuthor | Lee, Jong Joo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 406 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 89 | - |
dc.citation.endPage | 95 | - |
dc.identifier.bibliographicCitation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.406(1) : 89-95, 2011 | - |
dc.identifier.rimsid | 28747 | - |
dc.type.rims | ART | - |
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