Cited 12 times in
Quantitative T2* imaging of metastatic human breast cancer to brain in the nude rat at 3 T.
DC Field | Value | Language |
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dc.contributor.author | 송호택 | - |
dc.date.accessioned | 2014-12-20T16:27:32Z | - |
dc.date.available | 2014-12-20T16:27:32Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0952-3480 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92755 | - |
dc.description.abstract | This study uses quantitative T(2)* imaging to track ferumoxides--protamine sulfate (FEPro)-labeled MDA-MB-231BR-Luc (231BRL) human breast cancer cells that metastasize to the nude rat brain. Four cohorts of nude rats were injected intracardially with FEPro-labeled, unlabeled or tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)-treated (to induce apoptosis) 231BRL cells, or saline, in order to develop metastatic breast cancer in the brain. The heads of the rats were imaged serially over 3-4 weeks using gradient multi-echo and turbo spin-echo pulse sequences at 3 T with a solenoid receive-only 4-cm-diameter coil. Quantitative T(2)* maps of the whole brain were obtained by the application of single-exponential fitting to the signal intensity of T(2)* images, and the distribution of T(2)* values in brain voxels was calculated. MRI findings were correlated with Prussian blue staining and immunohistochemical staining for iron in breast cancer and macrophages. Quantitative analysis of T(2)* from brain voxels demonstrated a significant shift to lower values following the intracardiac injection of FEPro-labeled 231BRL cells, relative to animals receiving unlabeled cells, apoptotic cells or saline. Quartile analysis based on the T(2)* distribution obtained from brain voxels demonstrated significant differences (p < 0.0083) in the number of voxels with T(2)* values in the ranges 10-35 ms (Q1), 36-60 ms (Q2) and 61-86 ms (Q3) from 1 day to 3 weeks post-infusion of labeled 231BRL cells, compared with baseline scans. There were no significant differences in the distribution of T(2)* obtained from serial MRI in rats receiving unlabeled or TRAIL-treated cells or saline. Histologic analysis demonstrated isolated Prussian blue-positive breast cancer cells scattered in the brains of rats receiving labeled cells, relative to animals receiving unlabeled or apoptotic cells. Quantitative T(2)* analysis of FEPro-labeled metastasized cancer cells was possible even after the hypointense voxels were no longer visible on T(2)*-weighted images. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 325~334 | - |
dc.relation.isPartOf | NMR IN BIOMEDICINE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Brain Neoplasms/pathology | - |
dc.subject.MESH | Brain Neoplasms/secondary* | - |
dc.subject.MESH | Breast Neoplasms/pathology* | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Dextrans/metabolism | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Magnetite Nanoparticles | - |
dc.subject.MESH | Neoplasm Metastasis | - |
dc.subject.MESH | Neoplasm Transplantation | - |
dc.subject.MESH | Protamines/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Nude | - |
dc.title | Quantitative T2* imaging of metastatic human breast cancer to brain in the nude rat at 3 T. | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Radiology (영상의학) | - |
dc.contributor.googleauthor | Ho-Taek Song | - |
dc.contributor.googleauthor | Elaine K. Jordan | - |
dc.contributor.googleauthor | Bobbi K. Lewis | - |
dc.contributor.googleauthor | Eric Gold | - |
dc.contributor.googleauthor | Wei Liu | - |
dc.contributor.googleauthor | Joseph A. Frank | - |
dc.identifier.doi | 10.1002/nbm.1596 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A02080 | - |
dc.relation.journalcode | J02376 | - |
dc.identifier.eissn | 1099-1492 | - |
dc.identifier.pmid | 20949637 | - |
dc.subject.keyword | MRI | - |
dc.subject.keyword | quantification | - |
dc.subject.keyword | cellular tracking | - |
dc.subject.keyword | T2* map | - |
dc.subject.keyword | histogram | - |
dc.subject.keyword | brain metastasis | - |
dc.subject.keyword | breast cancer | - |
dc.subject.keyword | superparamagnetic iron oxides (SPIO) | - |
dc.contributor.alternativeName | Song, Ho Taek | - |
dc.contributor.affiliatedAuthor | Song, Ho Taek | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 24 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 325 | - |
dc.citation.endPage | 334 | - |
dc.identifier.bibliographicCitation | NMR IN BIOMEDICINE, Vol.24(3) : 325-334, 2011 | - |
dc.identifier.rimsid | 28739 | - |
dc.type.rims | ART | - |
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