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High microsatellite instability predicts good prognosis in intestinal-type gastric cancers

Authors
 Hyunki Kim  ;  Ji Yeong An  ;  Hoguen Kim  ;  Yong Chan Lee  ;  Sung Kwan Shin  ;  Sung Hoon Noh 
Citation
 Journal of Gastroenterology and Hepatology, Vol.26(3) : 585-592, 2011 
Journal Title
 Journal of Gastroenterology and Hepatology 
ISSN
 0815-9319 
Issue Date
2011
Abstract
BACKGROUND AND AIM: A subset of gastric cancers showed high microsatellite instability (MSI-H). The reported clinicopathological features of MSI-H gastric cancers are heterogeneous, and specific factors associated with prognosis have not been identified. METHODS: We analyzed the clinicopathological characteristics and prognostic factors in a large series (161 cases) of MSI-H gastric cancers, and compared the results to 315 cases of microsatellite-stable or low microsatellite-instable gastric cancers. RESULTS: The frequency of MSI-H gastric cancers was 9% (161/1786). MSI-H gastric cancers have distinct clinicopathological features, including female sex, older age, antral location, well-to-moderate differentiation, intestinal-type Lauren classification, expanding-type Ming classification, a non-signet-ring cell component, the presence of a mucinous component, a moderate-to-severe lymphoid stromal reaction, and a lower tumor stage. The MSI-H phenotype was associated with better prognosis (P = 0.044), and male sex (P = 0.035, hazard ratios [HR]: 0.23), intestinal-/mixed-type Lauren classification (P < 0.001, HR: 0.09) and lower tumor stages (1 and 2, P = 0.001, HR: 0.08) were independently-favorable prognostic factors. CONCLUSIONS: With unique clinicopathological features, intestinal-type MSI-H gastric cancers are associated with good prognosis and can be classified as a different subset of gastric cancers.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92740
DOI
10.1111/j.1440-1746.2010.06487.x
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김현기(Kim, Hyun Ki) ; 김호근(Kim, Ho Keun) ; 노성훈(Noh, Sung Hoon) ; 신성관(Shin, Sung Kwan) ; 이용찬(Lee, Yong Chan)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2010.06487.x/abstract
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