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High microsatellite instability predicts good prognosis in intestinal-type gastric cancers

Authors
 Hyunki Kim  ;  Ji Yeong An  ;  Sung Hoon Noh  ;  Sung Kwan Shin  ;  Yong Chan Lee  ;  Hoguen Kim 
Citation
 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.26(3) : 585-592, 2011 
Journal Title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
ISSN
 0815-9319 
Issue Date
2011
MeSH
Aged ; Chi-Square Distribution ; Female ; Gastrectomy ; Genetic Predisposition to Disease ; Humans ; Kaplan-Meier Estimate ; Logistic Models ; Lymph Node Excision ; Male ; Microsatellite Instability* ; Middle Aged ; Neoplasm Staging ; Phenotype ; Proportional Hazards Models ; Republic of Korea ; Risk Assessment ; Risk Factors ; Stomach Neoplasms/classification ; Stomach Neoplasms/genetics* ; Stomach Neoplasms/pathology ; Stomach Neoplasms/surgery ; Treatment Outcome
Keywords
gastric cancer ; intestinal-type ; Laurenclassification ; microsatellite instability ; prognostic factor
Abstract
BACKGROUND AND AIM: A subset of gastric cancers showed high microsatellite instability (MSI-H). The reported clinicopathological features of MSI-H gastric cancers are heterogeneous, and specific factors associated with prognosis have not been identified.

METHODS: We analyzed the clinicopathological characteristics and prognostic factors in a large series (161 cases) of MSI-H gastric cancers, and compared the results to 315 cases of microsatellite-stable or low microsatellite-instable gastric cancers.

RESULTS: The frequency of MSI-H gastric cancers was 9% (161/1786). MSI-H gastric cancers have distinct clinicopathological features, including female sex, older age, antral location, well-to-moderate differentiation, intestinal-type Lauren classification, expanding-type Ming classification, a non-signet-ring cell component, the presence of a mucinous component, a moderate-to-severe lymphoid stromal reaction, and a lower tumor stage. The MSI-H phenotype was associated with better prognosis (P = 0.044), and male sex (P = 0.035, hazard ratios [HR]: 0.23), intestinal-/mixed-type Lauren classification (P < 0.001, HR: 0.09) and lower tumor stages (1 and 2, P = 0.001, HR: 0.08) were independently-favorable prognostic factors.

CONCLUSIONS: With unique clinicopathological features, intestinal-type MSI-H gastric cancers are associated with good prognosis and can be classified as a different subset of gastric cancers.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1440-1746.2010.06487.x/abstract
DOI
10.1111/j.1440-1746.2010.06487.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyunki(김현기) ORCID logo https://orcid.org/0000-0003-2292-5584
Kim, Hogeun(김호근)
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Shin, Sung Kwan(신성관) ORCID logo https://orcid.org/0000-0001-5466-1400
Lee, Yong Chan(이용찬) ORCID logo https://orcid.org/0000-0001-8800-6906
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92740
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