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High plasma concentrations of transforming growth factor-β and tissue inhibitor of metalloproteinase-1: potential non-invasive predictors for electroanatomical remodeling of atrium in patients with non-valvular atrial fibrillation

 Sook Kyoung Kim  ;  Jae Hyung Park  ;  Jong Youn Kim  ;  Jong Il Choi  ;  Boyoung Joung  ;  Moon-Hyoung Lee  ;  Sung Soon Kim  ;  Young-Hoon Kim  ;  Hui-Nam Pak 
 CIRCULATION JOURNAL, Vol.75(3) : 557-564, 2011 
Journal Title
Issue Date
Adult ; Aged ; Atrial Fibrillation/blood* ; Atrial Fibrillation/pathology* ; Atrial Fibrillation/physiopathology ; Biomarkers/blood ; Biomechanical Phenomena ; Electrophysiologic Techniques, Cardiac ; Electrophysiological Phenomena/physiology ; Female ; Heart Atria/pathology* ; Heart Atria/physiopathology ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Retrospective Studies ; Stroke Volume/physiology ; Tissue Inhibitor of Metalloproteinase-1/blood* ; Transforming Growth Factor beta/blood*
Atrial fibrillation ; Left atrium ; Remodeling ; Tissue inhibitor of metalloproteinase ; Transforming growth factor-β
BACKGROUND: The degree of electroanatomical remodeling of the left atrial (LA) affects the clinical outcome after rhythm control of atrial fibrillation (AF). Our hypothesis was that plasma concentrations of transforming growth factor (TGF)-β and tissue inhibitor of metalloproteinase (TIMP)-1 reflect LA voltage and structural remodeling in patients with non-valvular AF. METHODS AND RESULTS: In the study, 242 patients (male 79.4%, 55.1 ± 11.0 years old) with AF (155 paroxysmal AF, 87 persistent AF) underwent catheter ablation. Pre-ablation plasma concentrations of TGF-β and TIMP-1 and the degree of electroanatomical remodeling quantified by LA voltage map (NavX) and 3D-CT were evaluated. The mean LA voltage and volume were compared in patients with high TGF-β (≥10.0 ng/ml, H-TGF) vs. low TGF-β (<10.0 ng/ml, L-TGF) and high TIMP-1 (≥1.1 ng/ml, H-TIMP) vs. low TIMP-1 (<1.1 ng/ml, L-TIMP). Patients with H-TGF had lower mean LA voltage (P=0.014) and greater LA volume (P=0.022), particularly, posterior venous LA volume (P=0.005) than those with L-TGF. In patients with H-TIMP, the mean LA voltage (P=0.019) was lower than those with L-TIMP. LA volume was significantly higher (P<0.001) in patients with ejection fraction ≤58% than those with >58%. CONCLUSIONS: In patients with non-valvular AF, high plasma concentrations TGF-β and TIMP-1 and low ejection fraction were closely related with electroanatomical remodeling of LA.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Sung Soon(김성순)
Kim, Jong Youn(김종윤) ORCID logo https://orcid.org/0000-0001-7040-8771
Pak, Hui Nam(박희남) ORCID logo https://orcid.org/0000-0002-3256-3620
Lee, Moon Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
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