118 159

Cited 38 times in

High plasma concentrations of transforming growth factor-β and tissue inhibitor of metalloproteinase-1: potential non-invasive predictors for electroanatomical remodeling of atrium in patients with non-valvular atrial fibrillation

DC FieldValueLanguage
dc.contributor.author김성순-
dc.contributor.author김종윤-
dc.contributor.author박희남-
dc.contributor.author이문형-
dc.contributor.author정보영-
dc.date.accessioned2014-12-20T16:26:33Z-
dc.date.available2014-12-20T16:26:33Z-
dc.date.issued2011-
dc.identifier.issn1346-9843-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92724-
dc.description.abstractBACKGROUND: The degree of electroanatomical remodeling of the left atrial (LA) affects the clinical outcome after rhythm control of atrial fibrillation (AF). Our hypothesis was that plasma concentrations of transforming growth factor (TGF)-β and tissue inhibitor of metalloproteinase (TIMP)-1 reflect LA voltage and structural remodeling in patients with non-valvular AF. METHODS AND RESULTS: In the study, 242 patients (male 79.4%, 55.1 ± 11.0 years old) with AF (155 paroxysmal AF, 87 persistent AF) underwent catheter ablation. Pre-ablation plasma concentrations of TGF-β and TIMP-1 and the degree of electroanatomical remodeling quantified by LA voltage map (NavX) and 3D-CT were evaluated. The mean LA voltage and volume were compared in patients with high TGF-β (≥10.0 ng/ml, H-TGF) vs. low TGF-β (<10.0 ng/ml, L-TGF) and high TIMP-1 (≥1.1 ng/ml, H-TIMP) vs. low TIMP-1 (<1.1 ng/ml, L-TIMP). Patients with H-TGF had lower mean LA voltage (P=0.014) and greater LA volume (P=0.022), particularly, posterior venous LA volume (P=0.005) than those with L-TGF. In patients with H-TIMP, the mean LA voltage (P=0.019) was lower than those with L-TIMP. LA volume was significantly higher (P<0.001) in patients with ejection fraction ≤58% than those with >58%. CONCLUSIONS: In patients with non-valvular AF, high plasma concentrations TGF-β and TIMP-1 and low ejection fraction were closely related with electroanatomical remodeling of LA.-
dc.description.statementOfResponsibilityopen-
dc.format.extent557~564-
dc.relation.isPartOfCirculation Journal-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleHigh plasma concentrations of transforming growth factor-β and tissue inhibitor of metalloproteinase-1: potential non-invasive predictors for electroanatomical remodeling of atrium in patients with non-valvular atrial fibrillation-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorSook Kyoung Kim-
dc.contributor.googleauthorJae Hyung Park-
dc.contributor.googleauthorJong Youn Kim-
dc.contributor.googleauthorJong Il Choi-
dc.contributor.googleauthorBoyoung Joung-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorSung Soon Kim-
dc.contributor.googleauthorYoung-Hoon Kim-
dc.contributor.googleauthorHui-Nam Pak-
dc.identifier.doi10.1253/circj.CJ-10-0758-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00573-
dc.contributor.localIdA00926-
dc.contributor.localIdA01776-
dc.contributor.localIdA02766-
dc.contributor.localIdA03609-
dc.relation.journalcodeJ00534-
dc.contributor.alternativeNameKim, Sung Soon-
dc.contributor.alternativeNameKim, Jong Youn-
dc.contributor.alternativeNamePak, Hui Nam-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.affiliatedAuthorKim, Sung Soon-
dc.contributor.affiliatedAuthorKim, Jong Youn-
dc.contributor.affiliatedAuthorPak, Hui Nam-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.rights.accessRightsfree-
dc.citation.volume75-
dc.citation.number3-
dc.citation.startPage557-
dc.citation.endPage564-
dc.identifier.bibliographicCitationCirculation Journal, Vol.75(3) : 557-564, 2011-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.