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The different infarct patterns between adulthood-onset and childhood-onset moyamoya disease

Authors
 H J Cho  ;  Y H Jung  ;  J H Heo  ;  D S Kim  ;  H S Nam  ;  Y D Kim 
Citation
 Journal of Neurology, Neurosurgery and Psychiatry, Vol.82(1) : 38-40, 2011 
Journal Title
 Journal of Neurology, Neurosurgery and Psychiatry 
ISSN
 0022-3050 
Issue Date
2011
Abstract
BACKGROUND AND PURPOSE: The pattern of infarctions based on the findings of diffusion-weighted image was assessed, and it was also investigated whether there are any age-specific differences in patients with moyamoya disease (MMD). METHODS: The subjects were 66 consecutive patients with MMD who had an acute cerebral infarction. Each ischaemic lesion was categorised into one of seven patterns (gyral, atypical territorial, honeycomb, classic territorial, multiple-dot, borderzone, deep lacunar) based on diffusion-weighted image findings. The patterns were compared between adulthood-onset MMD (A-MMD, ≥20 years old, 34 patients) and childhood/adolescent-onset MMD (C-MMD, <20 years old, 32 patients) according to their ages of infarct presentation. RESULTS: A total of 91 infarct patterns were observed from 66 patients. The gyral, atypical territorial, and honeycomb patterns, which are not usually seen in conventional stroke patients, were common in MMD (68.1%). Among all patterns, a gyral pattern was most common (40/91, 44.0%). Borderzone and deep lacunar patterns were infrequent. Gyral and borderzone patterns were more frequently seen in the C-MMD group, whereas a honeycomb pattern was not seen in young patients. Honeycomb pattern was more common at advanced vascular stages. Infarctions confined to the cortex were more common in the C-MMD group (26/32, 75.0%) than in A-MMD patients (14/34, 41.2%). CONCLUSIONS: Moyamoya disease showed various characteristic and age-specific infarct patterns. Different infarct patterns between the A-MMD and C-MMD groups may be associated with age-specific vulnerability of the brain to ischaemia, stage of arteriopathy or changes of abnormal collateral pathways.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92695
DOI
10.1136/jnnp.2009.181487
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실)
Yonsei Authors
김동석(Kim, Dong Seok) ; 김영대(Kim, Young Dae) ; 남효석(Nam, Hyo Suk) ; 정요한(Jung, Yo Han) ; 조현지(Cho, Hyun Ji) ; 허지회(Heo, Ji Hoe)
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Full Text
http://jnnp.bmj.com/content/82/1/38.long
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