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Cardiomyocytes from phorbol myristate acetate-activated mesenchymal stem cells restore electromechanical function in infarcted rat hearts
DC Field | Value | Language |
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dc.contributor.author | 김일권 | - |
dc.contributor.author | 박준희 | - |
dc.contributor.author | 송병욱 | - |
dc.contributor.author | 이문형 | - |
dc.contributor.author | 이세연 | - |
dc.contributor.author | 이창연 | - |
dc.contributor.author | 이충근 | - |
dc.contributor.author | 임소연 | - |
dc.contributor.author | 장양수 | - |
dc.contributor.author | 장우철 | - |
dc.contributor.author | 차민지 | - |
dc.contributor.author | 최은미 | - |
dc.contributor.author | 최은주 | - |
dc.contributor.author | 함온주 | - |
dc.contributor.author | 황기철 | - |
dc.contributor.author | 황혜진 | - |
dc.date.accessioned | 2014-12-20T16:24:49Z | - |
dc.date.available | 2014-12-20T16:24:49Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92669 | - |
dc.description.abstract | Despite the safety and feasibility of mesenchymal stem cell (MSC) therapy, an optimal cell type has not yet emerged in terms of electromechanical integration in infarcted myocardium. We found that poor to moderate survival benefits of MSC-implanted rats were caused by incomplete electromechanical integration induced by tissue heterogeneity between myocytes and engrafted MSCs in the infarcted myocardium. Here, we report the development of cardiogenic cells from rat MSCs activated by phorbol myristate acetate, a PKC activator, that exhibited high expressions of cardiac-specific markers and Ca(2+) homeostasis-related proteins and showed adrenergic receptor signaling by norepinephrine. Histological analysis showed high connexin 43 coupling, few inflammatory cells, and low fibrotic markers in myocardium implanted with these phorbol myristate acetate-activated MSCs. Infarct hearts implanted with these cells exhibited restoration of conduction velocity through decreased tissue heterogeneity and improved myocardial contractility. These findings have major implications for the development of better cell types for electromechanical integration of cell-based treatment for infarcted myocardium. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 296~301 | - |
dc.relation.isPartOf | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Analysis of Variance | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Blotting, Western | - |
dc.subject.MESH | Cell- and Tissue-Based Therapy/methods* | - |
dc.subject.MESH | Connexin 43/metabolism | - |
dc.subject.MESH | Cytokines/immunology | - |
dc.subject.MESH | Electrocardiography | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Fluorescent Antibody Technique | - |
dc.subject.MESH | In Situ Nick-End Labeling | - |
dc.subject.MESH | Isoproterenol/pharmacology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | MesenchymalStemCell Transplantation/methods | - |
dc.subject.MESH | MesenchymalStromalCells/cytology | - |
dc.subject.MESH | MesenchymalStromalCells/metabolism* | - |
dc.subject.MESH | Myocardial Contraction/drug effects | - |
dc.subject.MESH | Myocardial Contraction/physiology* | - |
dc.subject.MESH | Myocardial Infarction/therapy* | - |
dc.subject.MESH | Myocytes, Cardiac/cytology | - |
dc.subject.MESH | Myocytes, Cardiac/physiology* | - |
dc.subject.MESH | Norepinephrine/metabolism | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Receptors, Adrenergic/metabolism | - |
dc.subject.MESH | Reverse Transcriptase Polymerase Chain Reaction | - |
dc.subject.MESH | Tetradecanoylphorbol Acetate/metabolism | - |
dc.title | Cardiomyocytes from phorbol myristate acetate-activated mesenchymal stem cells restore electromechanical function in infarcted rat hearts | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Life Science (의생명과학부) | - |
dc.contributor.googleauthor | Heesang Song | - |
dc.contributor.googleauthor | Hye Jin Hwang | - |
dc.contributor.googleauthor | Woochul Chang | - |
dc.contributor.googleauthor | Byeong-Wook Song | - |
dc.contributor.googleauthor | Min-Ji Cha | - |
dc.contributor.googleauthor | Il-Kwon Kim | - |
dc.contributor.googleauthor | Soyeon Lim | - |
dc.contributor.googleauthor | Eun Ju Choi | - |
dc.contributor.googleauthor | Onju Ham | - |
dc.contributor.googleauthor | Chang Youn Lee | - |
dc.contributor.googleauthor | Jun-Hee Park | - |
dc.contributor.googleauthor | Se-Yeon Lee | - |
dc.contributor.googleauthor | Eunmi Choi | - |
dc.contributor.googleauthor | Chungkeun Lee | - |
dc.contributor.googleauthor | Myoungho Lee | - |
dc.contributor.googleauthor | Moon-Hyoung Lee | - |
dc.contributor.googleauthor | Sung-Hou Kim | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Ki-Chul Hwang | - |
dc.identifier.doi | 10.1073/pnas.1015873107/-/DCSupplemental | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01679 | - |
dc.contributor.localId | A02026 | - |
dc.contributor.localId | A02766 | - |
dc.contributor.localId | A02880 | - |
dc.contributor.localId | A03244 | - |
dc.contributor.localId | A03260 | - |
dc.contributor.localId | A03448 | - |
dc.contributor.localId | A03452 | - |
dc.contributor.localId | A03995 | - |
dc.contributor.localId | A04160 | - |
dc.contributor.localId | A04336 | - |
dc.contributor.localId | A04456 | - |
dc.contributor.localId | A04496 | - |
dc.contributor.localId | A04151 | - |
dc.contributor.localId | A00848 | - |
dc.contributor.localId | A03373-1 | - |
dc.relation.journalcode | J02550 | - |
dc.identifier.eissn | 1091-6490 | - |
dc.identifier.pmid | 21173226 | - |
dc.subject.keyword | cell therapy | - |
dc.subject.keyword | optical mapping | - |
dc.subject.keyword | differentiation | - |
dc.subject.keyword | heart infarction | - |
dc.subject.keyword | arrhythmia | - |
dc.contributor.alternativeName | Kim, Il Kwon | - |
dc.contributor.alternativeName | Park, Jun-Hee | - |
dc.contributor.alternativeName | Song, Byeong Wook | - |
dc.contributor.alternativeName | Lee, Moon Hyoung | - |
dc.contributor.alternativeName | Lee, Se Yeon | - |
dc.contributor.alternativeName | Lee, Chang Yeon | - |
dc.contributor.alternativeName | Lee, Chung Keun | - |
dc.contributor.alternativeName | Lim, So Yeon | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.alternativeName | Chang, Woo Chul | - |
dc.contributor.alternativeName | Cha, Min Ji | - |
dc.contributor.alternativeName | Choi, Eun Mi | - |
dc.contributor.alternativeName | Choi, Eun Ju | - |
dc.contributor.alternativeName | Ham, On Ju | - |
dc.contributor.alternativeName | Hwang, Ki Chul | - |
dc.contributor.alternativeName | Hwang, Hye Jin | - |
dc.contributor.affiliatedAuthor | Park, Jun-Hee | - |
dc.contributor.affiliatedAuthor | Song, Byeong Wook | - |
dc.contributor.affiliatedAuthor | Lee, Moon Hyoung | - |
dc.contributor.affiliatedAuthor | Lee, Se Yeon | - |
dc.contributor.affiliatedAuthor | Lee, Chang Yeon | - |
dc.contributor.affiliatedAuthor | Lee, Chung Keun | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Chang, Woo Chul | - |
dc.contributor.affiliatedAuthor | Cha, Min Ji | - |
dc.contributor.affiliatedAuthor | Choi, Eun Ju | - |
dc.contributor.affiliatedAuthor | Ham, On Ju | - |
dc.contributor.affiliatedAuthor | Hwang, Ki Chul | - |
dc.contributor.affiliatedAuthor | Hwang, Hye Jin | - |
dc.contributor.affiliatedAuthor | Choi, Eun Mi | - |
dc.contributor.affiliatedAuthor | Kim, Il Kwon | - |
dc.contributor.affiliatedAuthor | Lim, So Yeon | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 108 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 296 | - |
dc.citation.endPage | 301 | - |
dc.identifier.bibliographicCitation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol.108(1) : 296-301, 2011 | - |
dc.identifier.rimsid | 28686 | - |
dc.type.rims | ART | - |
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