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Cardiomyocytes from phorbol myristate acetate-activated mesenchymal stem cells restore electromechanical function in infarcted rat hearts

DC FieldValueLanguage
dc.contributor.author김일권-
dc.contributor.author박준희-
dc.contributor.author송병욱-
dc.contributor.author이문형-
dc.contributor.author이세연-
dc.contributor.author이창연-
dc.contributor.author이충근-
dc.contributor.author임소연-
dc.contributor.author장양수-
dc.contributor.author장우철-
dc.contributor.author차민지-
dc.contributor.author최은미-
dc.contributor.author최은주-
dc.contributor.author함온주-
dc.contributor.author황기철-
dc.contributor.author황혜진-
dc.date.accessioned2014-12-20T16:24:49Z-
dc.date.available2014-12-20T16:24:49Z-
dc.date.issued2011-
dc.identifier.issn0027-8424-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/92669-
dc.description.abstractDespite the safety and feasibility of mesenchymal stem cell (MSC) therapy, an optimal cell type has not yet emerged in terms of electromechanical integration in infarcted myocardium. We found that poor to moderate survival benefits of MSC-implanted rats were caused by incomplete electromechanical integration induced by tissue heterogeneity between myocytes and engrafted MSCs in the infarcted myocardium. Here, we report the development of cardiogenic cells from rat MSCs activated by phorbol myristate acetate, a PKC activator, that exhibited high expressions of cardiac-specific markers and Ca(2+) homeostasis-related proteins and showed adrenergic receptor signaling by norepinephrine. Histological analysis showed high connexin 43 coupling, few inflammatory cells, and low fibrotic markers in myocardium implanted with these phorbol myristate acetate-activated MSCs. Infarct hearts implanted with these cells exhibited restoration of conduction velocity through decreased tissue heterogeneity and improved myocardial contractility. These findings have major implications for the development of better cell types for electromechanical integration of cell-based treatment for infarcted myocardium.-
dc.description.statementOfResponsibilityopen-
dc.format.extent296~301-
dc.relation.isPartOfProceedings of the National Academy of Sciences of the United States of America-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnalysis of Variance-
dc.subject.MESHAnimals-
dc.subject.MESHBlotting, Western-
dc.subject.MESHCell- and Tissue-Based Therapy/methods*-
dc.subject.MESHConnexin 43/metabolism-
dc.subject.MESHCytokines/immunology-
dc.subject.MESHElectrocardiography-
dc.subject.MESHEnzyme-Linked Immunosorbent Assay-
dc.subject.MESHFluorescent Antibody Technique-
dc.subject.MESHIn Situ Nick-End Labeling-
dc.subject.MESHIsoproterenol/pharmacology-
dc.subject.MESHMale-
dc.subject.MESHMesenchymal Stem Cell Transplantation/methods-
dc.subject.MESHMesenchymal Stromal Cells/cytology-
dc.subject.MESHMesenchymal Stromal Cells/metabolism*-
dc.subject.MESHMyocardial Contraction/drug effects-
dc.subject.MESHMyocardial Contraction/physiology*-
dc.subject.MESHMyocardial Infarction/therapy*-
dc.subject.MESHMyocytes, Cardiac/cytology-
dc.subject.MESHMyocytes, Cardiac/physiology*-
dc.subject.MESHNorepinephrine/metabolism-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHReceptors, Adrenergic/metabolism-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHTetradecanoylphorbol Acetate/metabolism-
dc.titleCardiomyocytes from phorbol myristate acetate-activated mesenchymal stem cells restore electromechanical function in infarcted rat hearts-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorHeesang Song-
dc.contributor.googleauthorHye Jin Hwang-
dc.contributor.googleauthorWoochul Chang-
dc.contributor.googleauthorByeong-Wook Song-
dc.contributor.googleauthorMin-Ji Cha-
dc.contributor.googleauthorIl-Kwon Kim-
dc.contributor.googleauthorSoyeon Lim-
dc.contributor.googleauthorEun Ju Choi-
dc.contributor.googleauthorOnju Ham-
dc.contributor.googleauthorChang Youn Lee-
dc.contributor.googleauthorJun-Hee Park-
dc.contributor.googleauthorSe-Yeon Lee-
dc.contributor.googleauthorEunmi Choi-
dc.contributor.googleauthorChungkeun Lee-
dc.contributor.googleauthorMyoungho Lee-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorSung-Hou Kim-
dc.contributor.googleauthorYangsoo Jang-
dc.contributor.googleauthorKi-Chul Hwang-
dc.identifier.doi10.1073/pnas.1015873107/-/DCSupplemental-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01679-
dc.contributor.localIdA02026-
dc.contributor.localIdA02766-
dc.contributor.localIdA02880-
dc.contributor.localIdA03244-
dc.contributor.localIdA03260-
dc.contributor.localIdA03448-
dc.contributor.localIdA03452-
dc.contributor.localIdA03995-
dc.contributor.localIdA04160-
dc.contributor.localIdA04336-
dc.contributor.localIdA04456-
dc.contributor.localIdA04496-
dc.contributor.localIdA04151-
dc.contributor.localIdA00848-
dc.contributor.localIdA03373-1-
dc.relation.journalcodeJ02550-
dc.identifier.pmid21173226-
dc.subject.keywordcell therapy-
dc.subject.keywordoptical mapping-
dc.subject.keyworddifferentiation-
dc.subject.keywordheart infarction-
dc.subject.keywordarrhythmia-
dc.contributor.alternativeNameKim, Il Kwon-
dc.contributor.alternativeNamePark, Jun-Hee-
dc.contributor.alternativeNameSong, Byeong Wook-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.alternativeNameLee, Se Yeon-
dc.contributor.alternativeNameLee, Chang Yeon-
dc.contributor.alternativeNameLee, Chung Keun-
dc.contributor.alternativeNameLim, So Yeon-
dc.contributor.alternativeNameJang, Yang Soo-
dc.contributor.alternativeNameChang, Woo Chul-
dc.contributor.alternativeNameCha, Min Ji-
dc.contributor.alternativeNameChoi, Eun Mi-
dc.contributor.alternativeNameChoi, Eun Ju-
dc.contributor.alternativeNameHam, On Ju-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.contributor.alternativeNameHwang, Hye Jin-
dc.contributor.affiliatedAuthorPark, Jun-Hee-
dc.contributor.affiliatedAuthorSong, Byeong Wook-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.contributor.affiliatedAuthorLee, Se Yeon-
dc.contributor.affiliatedAuthorLee, Chang Yeon-
dc.contributor.affiliatedAuthorLee, Chung Keun-
dc.contributor.affiliatedAuthorJang, Yang Soo-
dc.contributor.affiliatedAuthorChang, Woo Chul-
dc.contributor.affiliatedAuthorCha, Min Ji-
dc.contributor.affiliatedAuthorChoi, Eun Ju-
dc.contributor.affiliatedAuthorHam, On Ju-
dc.contributor.affiliatedAuthorHwang, Ki Chul-
dc.contributor.affiliatedAuthorHwang, Hye Jin-
dc.contributor.affiliatedAuthorChoi, Eun Mi-
dc.contributor.affiliatedAuthorKim, Il Kwon-
dc.contributor.affiliatedAuthorLim, So Yeon-
dc.rights.accessRightsfree-
dc.citation.volume108-
dc.citation.number1-
dc.citation.startPage296-
dc.citation.endPage301-
dc.identifier.bibliographicCitationProceedings of the National Academy of Sciences of the United States of America, Vol.108(1) : 296-301, 2011-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Medical Research Center (임상의학연구센터) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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