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Pregabalin reduces post-operative pain after mastectomy: a double-blind, randomized, placebo-controlled study

Authors
 S. Y. KIM ; J. W. SONG ; Y. H. SHIM ; Y. J. AN ; S. PARK ; B. PARK 
Citation
 Acta Anaesthesiologica Scandinavica, Vol.55(3) : 290~296, 2011 
Journal Title
 Acta Anaesthesiologica Scandinavica 
ISSN
 0001-5172 
Issue Date
2011
Abstract
BACKGROUND: Pregabalin is used for the treatment of neuropathic pain and has shown analgesic efficacy in post-operative pain. The aim of this randomized, double-blinded, placebo-controlled trial (Clinical Trials.gov ID NCT00938548) was to investigate the efficacy and safety of pregabalin for reducing post-operative pain in patients after mastectomy. METHODS: Eighty-four women scheduled for elective mastectomy were randomly assigned to groups that received either pregabalin (75 mg) or placebo, 1 h before surgery and 12 h after the initial dose. Assessments of pain [verbal numerical rating scale (VNRS), at rest and with arm abduction] and side effects were performed at 1, 6, 24 and 48 h post-operatively. After discharge from the hospital, pain was assessed by telephone interview at post-operative 1 week and 1 month. RESULTS: VNRS scores for pain at rest were lower in the pregabalin group (n=42) than the placebo group (n=42) at 1, 24 and 48 h post-operatively (P<0.05). VNRS scores for pain with arm abduction were lower in the pregabalin group (n=42) than the placebo group (n=42) at 1 and 24 h, and 1 week post-operatively (P<0.05). Incidences of side effects such as nausea and vomiting, headache, dizziness and blurred vision were similar in both groups. CONCLUSION: Perioperative administration of pregabalin for a single day (75 mg twice daily) was easy, safe and effective in reducing post-operative pain in patients undergoing mastectomy.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/92629
DOI
10.1111/j.1399-6576.2010.02374.x
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Anesthesiology and Pain Medicine
1. 연구논문 > 1. College of Medicine > Dept. of Surgery
Yonsei Authors
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Link
 http://onlinelibrary.wiley.com/doi/10.1111/j.1399-6576.2010.02374.x/abstract
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