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Pregabalin reduces post-operative pain after mastectomy: a double-blind, randomized, placebo-controlled study

Authors
 S. Y. KIM  ;  J. W. SONG  ;  B. PARK  ;  S. PARK  ;  Y. J. AN  ;  Y. H. SHIM 
Citation
 ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol.55(3) : 290-296, 2011 
Journal Title
ACTA ANAESTHESIOLOGICA SCANDINAVICA
ISSN
 0001-5172 
Issue Date
2011
MeSH
Adult ; Analgesics/therapeutic use* ; Double-Blind Method ; Female ; Humans ; Mastectomy* ; Middle Aged ; Pain Measurement ; Pain, Postoperative/drug therapy* ; Pregabalin ; gamma-Aminobutyric Acid/adverse effects ; gamma-Aminobutyric Acid/analogs & derivatives* ; gamma-Aminobutyric Acid/therapeutic use
Abstract
BACKGROUND: Pregabalin is used for the treatment of neuropathic pain and has shown analgesic efficacy in post-operative pain. The aim of this randomized, double-blinded, placebo-controlled trial (Clinical Trials.gov ID NCT00938548) was to investigate the efficacy and safety of pregabalin for reducing post-operative pain in patients after mastectomy.

METHODS: Eighty-four women scheduled for elective mastectomy were randomly assigned to groups that received either pregabalin (75 mg) or placebo, 1 h before surgery and 12 h after the initial dose. Assessments of pain [verbal numerical rating scale (VNRS), at rest and with arm abduction] and side effects were performed at 1, 6, 24 and 48 h post-operatively. After discharge from the hospital, pain was assessed by telephone interview at post-operative 1 week and 1 month.

RESULTS: VNRS scores for pain at rest were lower in the pregabalin group (n=42) than the placebo group (n=42) at 1, 24 and 48 h post-operatively (P<0.05). VNRS scores for pain with arm abduction were lower in the pregabalin group (n=42) than the placebo group (n=42) at 1 and 24 h, and 1 week post-operatively (P<0.05). Incidences of side effects such as nausea and vomiting, headache, dizziness and blurred vision were similar in both groups.

CONCLUSION: Perioperative administration of pregabalin for a single day (75 mg twice daily) was easy, safe and effective in reducing post-operative pain in patients undergoing mastectomy.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/j.1399-6576.2010.02374.x/abstract
DOI
10.1111/j.1399-6576.2010.02374.x
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, So Yeon(김소연) ORCID logo https://orcid.org/0000-0001-5352-157X
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
Song, Jong Wook(송종욱) ORCID logo https://orcid.org/0000-0001-7518-2070
Shim, Yon Hee(심연희) ORCID logo https://orcid.org/0000-0003-1921-3391
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92629
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