Cited 56 times in
Pregabalin reduces post-operative pain after mastectomy: a double-blind, randomized, placebo-controlled study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김소연 | - |
dc.contributor.author | 박병우 | - |
dc.contributor.author | 박세호 | - |
dc.contributor.author | 송종욱 | - |
dc.contributor.author | 심연희 | - |
dc.date.accessioned | 2014-12-20T16:23:33Z | - |
dc.date.available | 2014-12-20T16:23:33Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0001-5172 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92629 | - |
dc.description.abstract | BACKGROUND: Pregabalin is used for the treatment of neuropathic pain and has shown analgesic efficacy in post-operative pain. The aim of this randomized, double-blinded, placebo-controlled trial (Clinical Trials.gov ID NCT00938548) was to investigate the efficacy and safety of pregabalin for reducing post-operative pain in patients after mastectomy. METHODS: Eighty-four women scheduled for elective mastectomy were randomly assigned to groups that received either pregabalin (75 mg) or placebo, 1 h before surgery and 12 h after the initial dose. Assessments of pain [verbal numerical rating scale (VNRS), at rest and with arm abduction] and side effects were performed at 1, 6, 24 and 48 h post-operatively. After discharge from the hospital, pain was assessed by telephone interview at post-operative 1 week and 1 month. RESULTS: VNRS scores for pain at rest were lower in the pregabalin group (n=42) than the placebo group (n=42) at 1, 24 and 48 h post-operatively (P<0.05). VNRS scores for pain with arm abduction were lower in the pregabalin group (n=42) than the placebo group (n=42) at 1 and 24 h, and 1 week post-operatively (P<0.05). Incidences of side effects such as nausea and vomiting, headache, dizziness and blurred vision were similar in both groups. CONCLUSION: Perioperative administration of pregabalin for a single day (75 mg twice daily) was easy, safe and effective in reducing post-operative pain in patients undergoing mastectomy. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 290~296 | - |
dc.relation.isPartOf | ACTA ANAESTHESIOLOGICA SCANDINAVICA | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Analgesics/therapeutic use* | - |
dc.subject.MESH | Double-Blind Method | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Mastectomy* | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Pain Measurement | - |
dc.subject.MESH | Pain, Postoperative/drug therapy* | - |
dc.subject.MESH | Pregabalin | - |
dc.subject.MESH | gamma-Aminobutyric Acid/adverse effects | - |
dc.subject.MESH | gamma-Aminobutyric Acid/analogs & derivatives* | - |
dc.subject.MESH | gamma-Aminobutyric Acid/therapeutic use | - |
dc.title | Pregabalin reduces post-operative pain after mastectomy: a double-blind, randomized, placebo-controlled study | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Anesthesiology (마취통증의학) | - |
dc.contributor.googleauthor | S. Y. KIM | - |
dc.contributor.googleauthor | J. W. SONG | - |
dc.contributor.googleauthor | B. PARK | - |
dc.contributor.googleauthor | S. PARK | - |
dc.contributor.googleauthor | Y. J. AN | - |
dc.contributor.googleauthor | Y. H. SHIM | - |
dc.identifier.doi | 10.1111/j.1399-6576.2010.02374.x | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A01475 | - |
dc.contributor.localId | A01524 | - |
dc.contributor.localId | A02060 | - |
dc.contributor.localId | A02196 | - |
dc.contributor.localId | A00616 | - |
dc.relation.journalcode | J00006 | - |
dc.identifier.eissn | 1399-6576 | - |
dc.identifier.pmid | 21288209 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/j.1399-6576.2010.02374.x/abstract | - |
dc.contributor.alternativeName | Kim, So Yeon | - |
dc.contributor.alternativeName | Park, Byeong Woo | - |
dc.contributor.alternativeName | Park, Se Ho | - |
dc.contributor.alternativeName | Song, Jong Wook | - |
dc.contributor.alternativeName | Shim, Yon Hee | - |
dc.contributor.affiliatedAuthor | Park, Byeong Woo | - |
dc.contributor.affiliatedAuthor | Park, Se Ho | - |
dc.contributor.affiliatedAuthor | Song, Jong Wook | - |
dc.contributor.affiliatedAuthor | Shim, Yon Hee | - |
dc.contributor.affiliatedAuthor | Kim, So Yeon | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 55 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 290 | - |
dc.citation.endPage | 296 | - |
dc.identifier.bibliographicCitation | ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol.55(3) : 290-296, 2011 | - |
dc.identifier.rimsid | 28665 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.