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Activation of the Occipital Cortex and Deactivation of the Default Mode Network During Working Memory in the Early Blind.

 Hae-Jeong Park ; Ji-Won Chun ; Jae-Jin Kim ; Jong Doo Lee ; Joong Il Kim ; Haeil Park ; Bumhee Park 
 Journal of the International Neuropsychological Society, Vol.22 : 1~16, 2011 
Journal Title
 Journal of the International Neuropsychological Society 
Issue Date
Although blind people heavily depend on working memory to manage daily life without visual information, it is not clear yet whether their working memory processing involves functional reorganization of the memory-related cortical network. To explore functional reorganization of the cortical network that supports various types of working memory processes in the early blind, we investigated activation differences between 2-back tasks and 0-back tasks using fMRI in 10 congenitally blind subjects and 10 sighted subjects. We used three types of stimulus sequences: words for a verbal task, pitches for a non-verbal task, and sound locations for a spatial task. When compared to the sighted, the blind showed additional activations in the occipital lobe for all types of stimulus sequences for working memory and more significant deactivation in the posterior cingulate cortex of the default mode network. The blind had increased effective connectivity from the default mode network to the left parieto-frontal network and from the occipital cortex to the right parieto-frontal network during the 2-back tasks than the 0-back tasks. These findings suggest not only cortical plasticity of the occipital cortex but also reorganization of the cortical network for the executive control of working memory. (JINS, 2011, 17, 1-16).
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Psychiatry
1. 연구논문 > 1. College of Medicine > Dept. of Life Science
1. 연구논문 > 1. College of Medicine > Yonsei Biomedical Research Center
1. 연구논문 > 1. College of Medicine > Dept. of Nuclear Medicine
Yonsei Authors
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