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Activation of the Occipital Cortex and Deactivation of the Default Mode Network During Working Memory in the Early Blind.

 Hae-Jeong Park  ;  Ji-Won Chun  ;  Bumhee Park  ;  Haeil Park  ;  Joong Il Kim  ;  Jong Doo Lee  ;  Jae-Jin Kim 
 Journal of the International Neuropsychological Society, Vol.22 : 1-16, 2011 
Journal Title
 Journal of the International Neuropsychological Society 
Issue Date
Although blind people heavily depend on working memory to manage daily life without visual information, it is not clear yet whether their working memory processing involves functional reorganization of the memory-related cortical network. To explore functional reorganization of the cortical network that supports various types of working memory processes in the early blind, we investigated activation differences between 2-back tasks and 0-back tasks using fMRI in 10 congenitally blind subjects and 10 sighted subjects. We used three types of stimulus sequences: words for a verbal task, pitches for a non-verbal task, and sound locations for a spatial task. When compared to the sighted, the blind showed additional activations in the occipital lobe for all types of stimulus sequences for working memory and more significant deactivation in the posterior cingulate cortex of the default mode network. The blind had increased effective connectivity from the default mode network to the left parieto-frontal network and from the occipital cortex to the right parieto-frontal network during the 2-back tasks than the 0-back tasks. These findings suggest not only cortical plasticity of the occipital cortex but also reorganization of the cortical network for the executive control of working memory. (JINS, 2011, 17, 1-16).
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
Yonsei Authors
김재진(Kim, Jae Jin) ORCID logo https://orcid.org/0000-0002-1395-4562
김중일(Kim, Joong Il)
박범희(Park, Bum Hee)
박해정(Park, Hae Jeong) ORCID logo https://orcid.org/0000-0002-4633-0756
이종두(Lee, Jong Doo)
전지원(Chun, Ji Won)
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