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Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men

 Ji Young Kim  ;  Jean Kyung Paik  ;  Oh Yoen Kim  ;  Hae Won Park  ;  Jin Hee Lee  ;  Yangsoo Jang  ;  Jong Ho Lee 
 ATHEROSCLEROSIS, Vol.215(1) : 189-195, 2011 
Journal Title
Issue Date
Adult ; C-Reactive Protein/metabolism ; Carotenoids/blood ; Carotenoids/pharmacology* ; DNA Damage/drug effects ; Dietary Supplements* ; Endothelium, Vascular/drug effects* ; Endothelium, Vascular/physiology ; Humans ; Hyperemia/physiopathology ; Lipoproteins, LDL/blood ; Male ; Manometry ; Middle Aged ; Oxidative Stress/drug effects ; Particle Size ; Superoxide Dismutase/blood ; Vascular Cell Adhesion Molecule-1/blood ; beta Carotene/metabolism
Lycopene ; Reactive hyperemia peripheral arterial tonometry ; Oxidative stress ; Endothelial function
OBJECTIVE: The objective was to determine the effects of lycopene supplementation on endothelial function assessed by reactive hyperemia peripheral arterial tonometry (RH-PAT) and oxidative stress. METHODS: Healthy men (n=126) were randomized to receive placebo (n=38), 6 mg (n=41), or 15 mg (n=37) lycopene daily for 8-week. RESULTS: Serum lycopene increased in a dose-dependent manner after 8-week supplementation (P<0.001). The 15 mg/day group had greater increase in plasma SOD activity (P=0.014) and reduction in lymphocyte DNA comet tail length (P=0.042) than the placebo group. Intragroup comparison revealed a 23% increase in RH-PAT index from baseline (1.45±0.09 vs. 1.79±0.12; P=0.032) in the 15 mg/day group after 8-week. hs-CRP, systolic blood pressure, sICAM-1 and sVCAM-1 significantly decreased, and β-carotene and LDL-particle size significantly increased only in the 15 mg/day group. Interestingly, the beneficial effect of lycopene supplementation on endothelial function (i.e., RH-PAT and sVCAM-1) were remarkable in subjects with relatively impaired endothelial cell function at initial level. Changes in RH-PAT index correlated with SOD activity (r=0.234, P=0.017) especially in the 15 mg lycopene/day group (r=0.485, P=0.003), lymphocyte DNA comet tail moment (r=-0.318, P=0.001), and hs-CRP (r=-0.238, P=0.011). In addition, changes in lycopene correlated with hs-CRP (r=-0.230, P=0.016) and SOD activity (r=0.205, P=0.037). CONCLUSION: An increase in serum lycopene after supplementation can reduce oxidative stress which may play a role in endothelial function.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Jang, Yang Soo(장양수) ORCID logo https://orcid.org/0000-0002-2169-3112
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