Cited 150 times in
Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men
DC Field | Value | Language |
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dc.contributor.author | 장양수 | - |
dc.date.accessioned | 2014-12-20T16:21:59Z | - |
dc.date.available | 2014-12-20T16:21:59Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 0021-9150 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92583 | - |
dc.description.abstract | OBJECTIVE: The objective was to determine the effects of lycopene supplementation on endothelial function assessed by reactive hyperemia peripheral arterial tonometry (RH-PAT) and oxidative stress. METHODS: Healthy men (n=126) were randomized to receive placebo (n=38), 6 mg (n=41), or 15 mg (n=37) lycopene daily for 8-week. RESULTS: Serum lycopene increased in a dose-dependent manner after 8-week supplementation (P<0.001). The 15 mg/day group had greater increase in plasma SOD activity (P=0.014) and reduction in lymphocyte DNA comet tail length (P=0.042) than the placebo group. Intragroup comparison revealed a 23% increase in RH-PAT index from baseline (1.45±0.09 vs. 1.79±0.12; P=0.032) in the 15 mg/day group after 8-week. hs-CRP, systolic blood pressure, sICAM-1 and sVCAM-1 significantly decreased, and β-carotene and LDL-particle size significantly increased only in the 15 mg/day group. Interestingly, the beneficial effect of lycopene supplementation on endothelial function (i.e., RH-PAT and sVCAM-1) were remarkable in subjects with relatively impaired endothelial cell function at initial level. Changes in RH-PAT index correlated with SOD activity (r=0.234, P=0.017) especially in the 15 mg lycopene/day group (r=0.485, P=0.003), lymphocyte DNA comet tail moment (r=-0.318, P=0.001), and hs-CRP (r=-0.238, P=0.011). In addition, changes in lycopene correlated with hs-CRP (r=-0.230, P=0.016) and SOD activity (r=0.205, P=0.037). CONCLUSION: An increase in serum lycopene after supplementation can reduce oxidative stress which may play a role in endothelial function. | - |
dc.description.statementOfResponsibility | open | - |
dc.format.extent | 189~195 | - |
dc.relation.isPartOf | ATHEROSCLEROSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | C-Reactive Protein/metabolism | - |
dc.subject.MESH | Carotenoids/blood | - |
dc.subject.MESH | Carotenoids/pharmacology* | - |
dc.subject.MESH | DNA Damage/drug effects | - |
dc.subject.MESH | Dietary Supplements* | - |
dc.subject.MESH | Endothelium, Vascular/drug effects* | - |
dc.subject.MESH | Endothelium, Vascular/physiology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hyperemia/physiopathology | - |
dc.subject.MESH | Lipoproteins, LDL/blood | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Manometry | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oxidative Stress/drug effects | - |
dc.subject.MESH | Particle Size | - |
dc.subject.MESH | Superoxide Dismutase/blood | - |
dc.subject.MESH | Vascular Cell Adhesion Molecule-1/blood | - |
dc.subject.MESH | beta Carotene/metabolism | - |
dc.title | Effects of lycopene supplementation on oxidative stress and markers of endothelial function in healthy men | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Ji Young Kim | - |
dc.contributor.googleauthor | Jean Kyung Paik | - |
dc.contributor.googleauthor | Oh Yoen Kim | - |
dc.contributor.googleauthor | Hae Won Park | - |
dc.contributor.googleauthor | Jin Hee Lee | - |
dc.contributor.googleauthor | Yangsoo Jang | - |
dc.contributor.googleauthor | Jong Ho Lee | - |
dc.identifier.doi | 10.1016/j.atherosclerosis.2010.11.036 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A03448 | - |
dc.relation.journalcode | J00260 | - |
dc.identifier.eissn | 1879-1484 | - |
dc.identifier.pmid | 21194693 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0021915010009755 | - |
dc.subject.keyword | Lycopene | - |
dc.subject.keyword | Reactive hyperemia peripheral arterial tonometry | - |
dc.subject.keyword | Oxidative stress | - |
dc.subject.keyword | Endothelial function | - |
dc.contributor.alternativeName | Jang, Yang Soo | - |
dc.contributor.affiliatedAuthor | Jang, Yang Soo | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 215 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 189 | - |
dc.citation.endPage | 195 | - |
dc.identifier.bibliographicCitation | ATHEROSCLEROSIS, Vol.215(1) : 189-195, 2011 | - |
dc.identifier.rimsid | 28645 | - |
dc.type.rims | ART | - |
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