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Comparison of peripapillary retinal nerve fiber layer thickness measured by spectral vs. time domain optical coherence tomography.

 Samin Hong  ;  Gong Je Seong  ;  Sung Soo Kim  ;  Sung Yong Kang  ;  Chan Yun Kim 
 CURRENT EYE RESEARCH, Vol.36(2) : 125-134, 2011 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Biometry ; Female ; Glaucoma, Open-Angle/diagnosis* ; Humans ; Intraocular Pressure ; Low Tension Glaucoma/diagnosis* ; Male ; Middle Aged ; Nerve Fibers/pathology* ; Optic Disk/pathology* ; ROC Curve ; Retinal Ganglion Cells/pathology* ; Tomography, Optical Coherence/instrumentation* ; Visual Field Tests ; Visual Fields ; Young Adult
Glaucoma ; Optical coherence tomography ; Retinal nerve fiber layer ; Spectral-domain ; Time-domain
PURPOSE: To compare the peripapillary retinal nerve fiber layer (RNFL) thickness measured by spectral and time domain optical coherence tomography (OCT). PATIENTS AND METHODS: One hundred and eighty-eight subjects (normal tension glaucoma, n = 80; primary open angle glaucoma, n = 49; healthy controls, n = 59) were included in this study. Peripapillary RNFL thickness was measured by an Optic Disc Cube 200 × 200 scan of the spectral domain Cirrus HD OCT and by a Fast RNFL scan of the time domain Stratus OCT. They were compared using linear regression (R(2)), Bland-Altman plots, weighted Kappa (K(w)) coefficients, and areas under the receiver operating characteristic curve (AROC). RESULTS: Except for the inferior quadrant, RNFL thickness measurements by Cirrus HD OCT were thinner than Stratus OCT (all p < 0.001); for the inferior quadrant, this tendency was vice versa (p  =  0.043). Average RNFL thicknesses of the two OCTs showed a good correlation (R(2), 0.852) but not excellent agreement (mean of difference, 4.0 μm; +1.96 SD, 10.7 μm; -1.96 SD, -18.6 μm). Regarding the probability codes, only the average RNFL thickness had almost perfect agreement (K(w), 0.983). In addition, Cirrus HD OCT had the largest AROC for the superior quadrant (0.795), but Stratus OCT had the largest AROC for average RNFL thickness (0.764) (p  =  0.281). CONCLUSIONS: Except for the inferior quadrant, the average and quadrants RNFL thickness measured by the Cirrus HD OCT were thinner than the Stratus OCT. Regarding discriminating power for glaucoma detection, the Cirrus HD OCT was better than the Stratus OCT for the superior and inferior quadrant RNFL thicknesses but not for the average RNFL thickness.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Sung Yong(강성용)
Kim, Sung Soo(김성수) ORCID logo https://orcid.org/0000-0002-0574-7993
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Hong, Sa Min(홍사민)
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