Cited 27 times in
MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김소영 | - |
dc.contributor.author | 김주항 | - |
dc.contributor.author | 선보경 | - |
dc.contributor.author | 송재진 | - |
dc.contributor.author | 오세은 | - |
dc.contributor.author | 응구엔응옥호안 | - |
dc.contributor.author | 최혜진 | - |
dc.date.accessioned | 2014-12-20T16:21:43Z | - |
dc.date.available | 2014-12-20T16:21:43Z | - |
dc.date.issued | 2011 | - |
dc.identifier.issn | 1021-335X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/92574 | - |
dc.description.abstract | The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been shown to activate mitogen-activated protein kinases (MAPKs) depending on caspase and mammalian sterile 20-like kinase 1 activations. However, the upstream molecule of MAPKs has not yet been identified. The mitogen-activated protein kinase kinase 1 (MEKK1) and the apoptosis signal-regulating kinase 1 (ASK1) are considered to be possible candidates for the action of MAPKKKs induced by TRAIL and the possibility of reactive oxygen species involvement has also been investigated. We found that MEKK1/MEKK4 as opposed to ASK1, are responsible for TRAIL-induced c-Jun NH2-terminal kinase (JNK) or p38 activation, and that their catalytic activity is repressed by the caspase-8 inhibitor, suggesting that the caspase-8 activation induced by TRAIL is indispensible for MEKK activation. The 14-3-3 θ was also shown to interact with and to dissociate from MEKK1 by TRAIL treatment, thus implicating the 14-3-3 protein as a negative regulator of MEKK1 activation. Taken together, we show herein that the upstream molecule of the TRAIL-induced MAPK activation is MEKK, as opposed to ASK1, via the mediation of its signal through JNK/p38 in a caspase-8-dependent manner. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.relation.isPartOf | ONCOLOGY REPORTS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | 14-3-3 Proteins/metabolism | - |
dc.subject.MESH | Antibodies/pharmacology | - |
dc.subject.MESH | Cell Line, Tumor | - |
dc.subject.MESH | Enzyme Activation/drug effects | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | JNK Mitogen-Activated Protein Kinases/metabolism* | - |
dc.subject.MESH | MAP Kinase Kinase 4/antagonists & inhibitors | - |
dc.subject.MESH | MAP Kinase Kinase 4/genetics | - |
dc.subject.MESH | MAP Kinase Kinase Kinase 1/antagonists & inhibitors | - |
dc.subject.MESH | MAP Kinase Kinase Kinase 1/immunology | - |
dc.subject.MESH | MAP Kinase Kinase Kinase 1/metabolism | - |
dc.subject.MESH | MAP Kinase Kinase Kinase 1/physiology* | - |
dc.subject.MESH | MAP Kinase Kinase Kinase 4/antagonists & inhibitors | - |
dc.subject.MESH | MAP Kinase Kinase Kinase 4/immunology | - |
dc.subject.MESH | MAP Kinase Kinase Kinase 4/metabolism | - |
dc.subject.MESH | MAP Kinase Kinase Kinase 4/physiology* | - |
dc.subject.MESH | Phosphorylation/drug effects | - |
dc.subject.MESH | Protein Binding/drug effects | - |
dc.subject.MESH | Protein Binding/physiology | - |
dc.subject.MESH | RNA, Small Interfering/pharmacology | - |
dc.subject.MESH | TNF-Related Apoptosis-Inducing Ligand/pharmacology* | - |
dc.subject.MESH | p38 Mitogen-Activated Protein Kinases/metabolism* | - |
dc.title | MEKK1/MEKK4 are responsible for TRAIL-induced JNK/p38 phosphorylation | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Yonsei Biomedical Research Center (연세의생명연구원) | - |
dc.contributor.googleauthor | Bo K Sun | - |
dc.contributor.googleauthor | Joo-Hang Kim | - |
dc.contributor.googleauthor | Hoan N. Nguyen | - |
dc.contributor.googleauthor | Seeun Oh | - |
dc.contributor.googleauthor | So Y. Kim | - |
dc.contributor.googleauthor | Hye J. | - |
dc.contributor.googleauthor | Hye J. Choi | - |
dc.contributor.googleauthor | Yong J. Lee | - |
dc.contributor.googleauthor | Jae J. Song | - |
dc.identifier.doi | 10.3892/or.2010.1079 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00945 | - |
dc.contributor.localId | A01933 | - |
dc.contributor.localId | A02378 | - |
dc.contributor.localId | A02636 | - |
dc.contributor.localId | A04219 | - |
dc.contributor.localId | A00621 | - |
dc.contributor.localId | A02056 | - |
dc.relation.journalcode | J02419 | - |
dc.identifier.eissn | 1791-2431 | - |
dc.identifier.pmid | 21152872 | - |
dc.contributor.alternativeName | Kim, So Young | - |
dc.contributor.alternativeName | Kim, Joo Hang | - |
dc.contributor.alternativeName | Sun, Bo Kyung | - |
dc.contributor.alternativeName | Song, Jae Jin | - |
dc.contributor.alternativeName | Oh, Se Eun | - |
dc.contributor.alternativeName | Nguyen, Hoan N. | - |
dc.contributor.alternativeName | Choi, Hye Jin | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hang | - |
dc.contributor.affiliatedAuthor | Sun, Bo Kyung | - |
dc.contributor.affiliatedAuthor | Oh, Se Eun | - |
dc.contributor.affiliatedAuthor | Nguyen, Hoan N. | - |
dc.contributor.affiliatedAuthor | Choi, Hye Jin | - |
dc.contributor.affiliatedAuthor | Kim, So Young | - |
dc.contributor.affiliatedAuthor | Song, Jae Jin | - |
dc.rights.accessRights | free | - |
dc.citation.volume | 25 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 537 | - |
dc.citation.endPage | 544 | - |
dc.identifier.bibliographicCitation | ONCOLOGY REPORTS, Vol.25(2) : 537-544, 2011 | - |
dc.identifier.rimsid | 28639 | - |
dc.type.rims | ART | - |
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