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18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer.

Authors
 Hyuk Hur  ;  Nam Kyu Kim  ;  Hoguen Kim  ;  Jung Bai Ahn  ;  Ki Chang Keum  ;  Kang Young Lee  ;  Byung Soh Min  ;  Mijin Yun 
Citation
 Journal of Surgical Oncology, Vol.103(1) : 17-24, 2011 
Journal Title
 Journal of Surgical Oncology 
ISSN
 0022-4790 
Issue Date
2011
Abstract
BACKGROUND: This study aims to evaluate the efficacy of (18)F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. METHODS: Maximum standardized uptake value (SUV) was measured for 37 patients who underwent (18)F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. RESULTS: A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean post-SUV and the mean RR were significantly different between pCR (+) patients (N = 13) and pCR (-) patients (N = 24) (2.7 vs. 4.8, P < 0.001, 73.9% vs. 58.7%, P = 0.009). With a 3.35 cut-off value for the post-SUV by receiver operating characteristic analysis, 84.6% sensitivity, 79.2% specificity, and 81.2% overall accuracy were obtained for discriminating between pCR (+) and pCR (-) (area under the curve = 0.885, P < 0.001). CONCLUSIONS: (18)F-FDG PET is potentially useful as a method for assessing tumor response after preoperative CRT for rectal cancer. Post-SUV and RR were significantly associated with pathological treatment response, especially in pCR.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/92559
DOI
10.1002/jso.21736
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
금기창(Keum, Ki Chang) ; 김남규(Kim, Nam Kyu) ; 김호근(Kim, Ho Keun) ; 민병소(Min, Byung Soh) ; 안중배(Ahn, Joong Bae) ; 윤미진(Yun, Mi Jin) ; 이강영(Lee, Kang Young) ; 허혁(Hur, Hyuk)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.21736/abstract
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